ACS News Service Weekly PressPac -- Octobe...( als for instance insert genes into on...)

ACS News Service Weekly PressPac -- October 11, 2006

als, for instance, insert genes into only a small percentage of cells and do not degrade in the body.

Robert Langer and colleagues used laboratory experiments to show that the polymers can deliver DNA to human liver cancer cells. Their report is scheduled for the current (Oct. 15) issue of the weekly Journal of the American Chemical Society.

One polymer has potential for carrying genes to the supply of tiny blood vessels that enables cancer cells to grow and spread. "We are currently testing the targeting effects of this polymer on endothelial cells, and it is envisioned that this delivery system could permit localization and transfection of the tumor vasculature for cancer therapies," the report states.

ARTICLE #1 FOR IMMEDIATE RELEASE
"Synthesis of Poly (beta-amino Ester)s with Thiol-Reactive Side Chains for DNA Delivery"

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http://pubs.acs.org/cgi-bin/sample.cgi/jacsat/2006/128/i39/pdf/ja061570n.pdf
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http://pubs.acs.org/cgi-bin/sample.cgi/jacsat/2006/128/i39/html/ja061570n.html

CONTACT:
Robert Langer, Ph.D.
Massachusetts Institute of Technology
Cambridge, Massachusetts
Phone: 617-253-3123
Fax: 617-258-8827
Email: rlanger@mit.edu

ARTICLE #2 FOR IMMEDIATE RELEASE
New microscope reveals deadly secret life of malaria parasites inside human cells
Bioinorganic Chemistry

Scientists at Georgetown University are describing the first use of a new microscope technology to capture images of live malaria parasites inside human red blood cells. They say the advance could be important in efforts to understand the malaria parasite's deadly tendency to become resistant to anti-mala
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Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society
16-Oct-2006

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