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ACS News Service Weekly PressPac -- October 11, 2006

ria drugs and in developing new drugs and vaccines for the disease.

Malaria kills about one million people worldwide each year. About 90 percent are in Africa and 70 percent are children under the age of five.

Georgetown University researcher Paul D. Roepe and colleagues explain that the malaria parasite's unusual biology makes it difficult to visualize these organisms while they are alive and active inside human cells. In order to overcome the limitations of existing imaging techniques, the researchers modified a spinning disk confocal microscope (SDCM).

They describe the SDCM and its initial uses in two papers scheduled for publication in the current (Oct. 17) issue of the weekly ACS journal, Biochemistry. The modified SDCM captured unprecedented images of live malaria parasites, which Roepe and colleagues publish for the first time in one of the papers.

ARTICLE #2 FOR IMMEDIATE RELEASE
"Spinning Disk Confocal Microscopy of Live, Intraerythrocytic Malarial Parasites. 1. Quantification of Hemozoin Development for Drug Sensitive versus Resistant Malaria"
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"Spinning Disk Confocal Microscopy of Live, Intraerythrocytic Malarial Parasites. 2. Altered Vacuolar Volume Regulation in Drug Resistant Malaria"
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http://pubs.acs.org/cgi-bin/sample.cgi/bichaw/2006/45/i41/pdf/bi0610348.pdf
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Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society
16-Oct-2006


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