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ACS News Service weekly press package - May 30, 2006

ely unexpected discovery that ozone may be produced in the body. Ozone is a high-energy form of oxygen most familiar as an air pollutant. That research showed that ozone can cause pathological changes in cholesterol and other molecules in the body. The changes produce toxic compounds called "atheronals" that are present in atherosclerotic plaques removed from patients with blood vessel disease.

In their new research, scheduled for publication in the June 13 issue of Biochemistry, Paul Wentworth, Jr., and colleagues report that atheronals do have the potential to cause plaques. Atheronals accelerate or stimulate a number of processes regarded as critical for formation of atherosclerotic plaques, they found.

The Biochemistry report raises the possibility that atheronals may originate in part from ozone inhaled into the lung from polluted air. "As such, the atheronals may be a heretofore unrecognized chemical player in the known linkage between environmental pollution and cardiovascular disease," the report states.

ARTICLE #1
"Proatherogenic Effects of the Cholesterol Ozonolysis Products, Atheronal-A and Atheronal-B."

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CONTACT:
Paul Wentworth, Jr., Ph.D., FRSC
The Scripps Research Institute
Phone: 858-784-2576
Fax: 858-784-2593
Email: paulw@scripps.edu, paul.wentworth@bioch.ox.ac.uk

ARTICLE #2

A dozen cloves of garlic a day keeps the doctor away?
Journal of Agricultural & Food Chemistry

The classic fairy tale Goldilock
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Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society
30-May-2006


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