ACS Weekly PressPac -- Jul...( emical Society In an advance toward ...)

ACS Weekly PressPac -- July 12, 2006

emical Society
In an advance toward developing an effective treatment for ciguatera (sig-wa-TEHR-a) poisoning -- the world's most common type of seafood poisoning -- scientists have synthesized the toxin responsible for the disease. Estimates suggest that up to one million cases of ciguatoxin poisoning occur worldwide each year. In addition to serious acute symptoms, ciguatoxin poisons often cause long-lasting neurological problems.

The advance, by Masayuki Inoue, Masahiro Hirama and colleagues, means that a more abundant supply of ciguatoxin will be available for drug development and other research. In a report scheduled for the August 2 issue of the Journal of the American Chemical Society, Inoue and Hirama note that the scanty supply of natural ciguatoxin has been a major barrier to alleviating the disease.

Scientists had to grind and process 8,800 pounds of moray eel to obtain 0.00001 ounce of natural ciguatoxin. In 1989, chemists used that fraction of a drop to determine ciguatoxin's molecular structure. That key step enabled chemists to begin work on ways of making larger quantities of synthetic ciguatoxin. Inoue and Hirama state that their achievement "will accelerate biological studies as well as the development of strategies for controlling ciguatera seafood poisoning."

ARTICLE #1
"Total Synthesis of Ciguatoxin and 51-HydroxyCTX3C"

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CONTACT:
Masayuki Inoue, Ph.D.
Tohoku University
Sendai, Japan
Phone: +81-22-795-6565
Fax: +81-22-795-6563
Email: inoue@ykbsc.chem.tohoku
'"/>

Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society
17-Jul-2006

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