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ACS Weekly PressPac -- July 12, 2006

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Hugo Destaillats, Ph.D.
Lawrence Berkeley National Laboratory
PHONE: 510-486-5897
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University of California, Berkeley
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ARTICLE#4 EMBARGOED FOR 9 a.m., Eastern Time, July 17, 2006
Pulling Genes' Strings

Chemical & Engineering News
A once-obscure field called epigenetics is rocketing into prominence in molecular biology and medicine as scientists explore and apply a phenomenon in which the function of genes can change without any change in the sequence of nuclear DNA, according to an article scheduled for the July 17 issue of Chemical & Engineering News reports.

One sign of epigenetics' potential is the U. S. Food and Drug Administration's recent approval of two drugs for treating blood disorders that work by causing epigenetic changes, the article notes. Written by Ivan Amato, the article explains how epigenetics research is focusing attention on chromatin, the structural material of chromosomes, which consists of a complex of DNA and protein.

DNA provides the instructions that define humans and other organisms, but chromatin has a central role in determining how the information in DNA is used. Addition of methyl (CH3) groups to specific locations in chromatin's DNA, for instance, marks genetic sequences in the same stretch as "do not transcribe." Both of the newly approved drugs work by blocking DNA methylation in that way. Other drugs that work epigenetically also are on the way, in addition to powerful new insights into health and disease, Amato notes in the article.

ARTICLE #4
"Pulling Genes' Strings: Genes would be hardl
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Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society
17-Jul-2006


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