AVELOX as effective as multi-dose combination therapy for intra-abdominal ...( important because complicated intra-ab...)

important because complicated intra-abdominal infections are typically caused by mixed bacteria and require both surgery or drainage of the infection site and broad-spectrum antibiotic therapy for effective treatment," said Mark Malangoni, M.D., lead study investigator and Professor of Surgery at Case Western Reserve University School of Medicine and Surgeon-in-Chief at MetroHealth Medical Center in Cleveland. "AVELOX has demonstrated potent activity against the bacteria most common in these infections and is a safe and effective treatment. It also can be continued as a once-daily tablet, which is convenient for patients."

AVELOX is indicated to treat polymicrobial cIAI infections, including infections caused by mixed aerobic and anaerobic bacteria (bacteria that thrive without oxygen) commonly seen in patients with cIAI.(2,3)

"One fixed dose of AVELOX offers physicians a convenient treatment option with no dose adjustment required as symptoms improve and patients transition from intravenous (hospital-based) to oral therapy," said Joseph S. Solomkin, M.D., Professor in the Department of Surgery and Director of Research of the Division of Trauma/Critical Care at the University of Cincinnati College of Medicine, and a leading expert in the field. "The key benefit of staying with the same agent is the knowledge that the patient responded to it intravenously and can continue with the oral form when they leave the hospital."

Complicated intra-abdominal infections are caused by disease, trauma or surgery in the abdomen that can allow bacteria to leak from the gastrointestinal tract into adjacent tissue. The biggest challenge to effective cIAI treatment is early recognition of the problem; the sooner the infection is diagnosed, the greater the chance that the physician will prescribe an effective treatment.(4)

In the absence of effective cIAI therapy, treatment failure and mortality rates increase. Clinical practice guidelines re
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25-Jul-2006

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