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AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers

vated even in the absence of circulating levels of the drug between doses. Other genes directly related to IMPDH inhibition showed similar response characteristics.

"AvalonRx, our proprietary gene expression platform, enabled us to identify a set of 34 genes that reflect the mechanism-based activity of AVN944," said David Bol, Ph.D., Senior Vice President of Product and Pharmaceutical Development at Avalon. "These gene markers correlate with the biochemical effects of AVN944 on protein function, which we believe will result in tumor cell apoptosis at the right doses. Our goal for the current Phase I study is to achieve those dose levels in patients. It is very encouraging that we have not seen any drug related adverse events even though we are already seeing biomarker movements consistent with significant inhibition of the IMPDH enzyme. This indicates the potential for a good therapeutic window. Additionally, these data showcase the power of the AvalonRx technology in understanding the pharmacologic, pharmacodynamic and biologic activity of a drug on patients in early clinical studies."

This analysis of the trial data was intended to describe how these biomarkers correlate with biologic activity of the drug in patients as the doses escalate. When comparing patients with different hematologic cancers, examination of the complete set of markers clearly demonstrated the utility of comprehensive gene expression analysis in clinical trials by distinguishing individuals with similar diseases, as well as patients with different malignancies, based on the makeup of their disease prior to drug administration as well as the different nature of the cellular response following drug administration.


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Contact: Wendy Lau
wendy.lau1@eurorscg.com
212-845-4272
Euro RSCG Life NRP
11-Dec-2006


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