HOME >> BIOLOGY >> NEWS
Abundance of myostatin in infected swine may result in reduced muscle mass

CHAMPAIGN, Ill. -- A study looking at chronic infectious respiratory diseases that affect most swine during their critical growing stage has shed new light on the reasons for restricted weight gain and reduced muscle mass.

In the November issue of the Journal of Nutrition, scientists at the University of Illinois at Urbana-Champaign report that the production of inflammatory cytokines by immune cells appears to be responsible for declines of both protein accretion and weight gain in swine infected with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV).

The study also suggests that myostatin, a protein that limits muscle growth, is overproduced during infection, thereby reducing the growth of skeletal muscle, said Rodney W. Johnson, a professor in the department of animal sciences and the interdisciplinary Division of Nutritional Sciences.

Johnson and colleagues isolated pigs in disease-containment chambers and exposed different experimental groups to the bacterium Mycoplasma hyopneumoniae and/or PRRSV.

Almost all U.S. swine are exposed to the bacterium in production facilities, while about 60 percent are exposed to PRRSV. These pathogens open the way for other infectious agents. During the pivotal growing stage, pigs are at the most risk and suffer from cough, fevers and depressed appetite. Reduced market weight or increased time for pigs to reach a desired market weight can be a substantial cost to producers.

Infection from the bacterium alone did not reduce weight gain compared with the control group during the four-week-long experiment, but it did lead to the development of lesions that affected 8 percent of the total lung area in infected pigs. The finding was similar to earlier work in Johnson's laboratory. However, the introduction of PRRSV caused damage to the lungs from the bacterium to jump to 40 percent.

"One thing the virus does is suppress the immune system," Johnso
'"/>

Contact: Jim Barlow, Life Sciences Editor
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
17-Nov-2004


Page: 1 2

Related biology news :

1. Identified mechanism in the malaria parasite to help it adapt to infected individuals
2. Major breakthrough in understanding how HIV interferes with infected cell division
3. Manganese levels increase in scrapie-infected sheep before clinical symptoms develop
4. Anti-herpes treatment reduces HIV levels in women infected with both viruses
5. Antiretroviral resistance testing in HIV infected patients improves health and saves costs
6. Meth promotes spread of virus in HIV-infected users
7. HIVs cellular kiss of death explains loss of uninfected T cells in AIDS
8. Higher risk for cervical cancer seen among women infected with multiple HPV types
9. Viral protein helps infected T cells stick to uninfected cells
10. Zinc supplements safe for HIV-infected children
11. Mosquitoes are more attracted to individuals infected with malaria

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/30/2016)... 2016 Not many of us realize that we spend ? of our ... need to do it well. Inadequate sleep levels have been found to lead to ... and even cancer. Maybe now is the best time to rethink how ... to manage their sleep quality? Continue Reading ... ...
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The ... Identification Systems) ... Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of ...
(Date:11/22/2016)... 22, 2016   MedNet Solutions , an innovative ... of clinical research, is pleased to announce that the ... and Life Sciences Awards as "Most Outstanding in ... unprecedented year of recognition and growth for MedNet, which ... years. iMedNet ™ , MedNet,s ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... New York , November 30, 2016 ... consolidated as a few players hold a dominant share ... Group, Charles River Laboratories International, Inc., and Merck KGaA, ... market in 2015. Transparency Market Research observes that these ... are focused on development products that are do not ...
(Date:11/30/2016)... 30, 2016  Tempus, a technology company focused ... Penn,s Abramson Cancer Center have partnered to better ... to immunotherapy treatment based on next generation genomic ... of a research collaboration, Tempus will provide sequencing ... patient data to Penn. Utilizing next-generation sequencing, machine ...
(Date:11/30/2016)... (PRWEB) , ... November 30, 2016 , ... SSCI, the ... to discuss the implications of the latest FDA guidance on pharmaceutical cocrystals as ... 2016 in Cambridge, MA. , The event follows the successful November 15th ...
(Date:11/30/2016)... (PRWEB) , ... November 30, 2016 , ... ... discovery and development of precision treatments for neurodegenerative diseases, today announced that all ... (announced on November 3, 2016) blocked propagation of toxic, prion-like forms of Amyloid ...
Breaking Biology Technology:
Cached News: