HOME >> BIOLOGY >> NEWS
'Accelerated evolution' converts RNA enzyme to DNA enzyme in vitro

This "evolutionary conversion" provides a modern-day snapshot of how life as we understand it may have first evolved out of the earliest primordial mix of RNA-like molecules-sometimes referred to as the "pre-RNA world"-into a more complex form of RNA-based life (or the "RNA world") and eventually to cellular life based on DNA and proteins. Nucleic acids are large complex molecules that store and convey genetic information, but can also function as enzymes.

While the transfer of sequence information between two different classes of nucleic acid-like molecules-between RNA and DNA, for example-is straightforward because it relies on the one-to-one correspondence of the double helix pairing, transferring catalytic function is significantly more difficult because function cannot be conveyed sequentially. The present study demonstrates that the "evolutionary conversion" of an RNA enzyme to a DNA enzyme with the same function is possible, however, through the acquisition of a few critical mutations.

The study was released in an advance online version of the journal Chemistry & Biology.

Scripps Research Professor Gerald F. Joyce, a member of the Skaggs Institute for Chemical Biology whose laboratory conducted the study, said, "During early life on earth both genetic information and catalytic function were thought to reside only in RNA. In our study, the evolutionary transition from an RNA to a DNA enzyme represents a genuine change, rather than a simple expansion, of the chemical basis for catalytic function. This means that similar evolutionary pathways may exist between other classes of nucleic acid-like molecules. These findings could help answer some fundamental questions concerning the basic structure of life and how it evolved over time."

As Francis Crick, the Nobel laureate who, along with James Watson uncovered the double helix structure of DNA, articulated in 1970, all known organisms operate according to the central dogma of mo
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
27-Mar-2006


Page: 1 2 3

Related biology news :

1. Ewwwww! UCLA anthropologist studies evolutions disgusting side
2. Researchers untangle nature of regressive evolution in cavefish
3. Quiet revolution may herald new RNA therapeutics
4. Modern humans, not Neandertals, may be evolutions odd man out
5. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
6. Mobile DNA part of evolutions toolbox
7. On a flys wing, scientists tally evolutions winners and losses
8. Northeast Sun Grant Institute at Cornell spurs green revolution
9. Scientist converts UK nuclear energy policy
10. Protecting virus offers instant flu protection and converts flu infections into their own vaccines
11. Newly identified enzyme group converts protein into cellular traffic signal

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Accelerated evolution converts RNA enzyme DNA enzyme vitro

(Date:7/24/2014)... N.J. A yearlong study funded by the New ... Edward J. Bloustein School of Planning and Public Policy ... in Sandy-affected towns are skeptical about the likelihood of ... survey respondents, 45 percent indicated they were "pessimistic" or ... by Superstorm Sandy would be rebuilt better than they ...
(Date:7/24/2014)... team of researchers led by the University of York ... conservation in the Western Indian Ocean. , The ... point to a revolution in the management of marine ... more than 11,000 km in the region now ... are zones of the seas and coasts designed to ...
(Date:7/24/2014)... on his work with a new drug that successfully treated ... Houston has received a $250,000 grant to expand his research ... to treat a wider range of autoimmune diseases., Chandra Mohan, ... Engineering at UH, previously published a study in Arthritis Research ... successfully treated lupus in mice and reduced the number of ...
Breaking Biology News(10 mins):Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2Western Indian Ocean communities play vital role in conservation 2Biomedical engineer looks at new applications for novel lupus drug 2Biomedical engineer looks at new applications for novel lupus drug 3
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
(Date:7/24/2014)... sophisticated equipment, trained personnel, and detection dogs to ... attacks. A revolutionary new electronic chip with nano-sized ... much easier. , The groundbreaking nanotechnology-inspired sensor, devised ... ,s School of Chemistry and Center for Nanoscience ... Tracense, picks up the scent of explosives molecules ...
(Date:7/24/2014)... yet to materialise. Yet, scientists are making progress ... faster. One such approach relies on quantum dotsa ... an electric field. A new study demonstrates that ... dots (TQDs) with electrical impulses can help better ... TQDs be used as quantum information units, which ...
(Date:7/24/2014)... Although most natural and synthetic processes prefer to ... potential or energyit is within the realm of ... experience constant changes in energy and phases, such ... These conditions allow humans to regulate their body ... rumble with seismic activity. , But even ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2
Cached News: