HOME >> BIOLOGY >> NEWS
'Accelerated evolution' converts RNA enzyme to DNA enzyme in vitro

This "evolutionary conversion" provides a modern-day snapshot of how life as we understand it may have first evolved out of the earliest primordial mix of RNA-like molecules-sometimes referred to as the "pre-RNA world"-into a more complex form of RNA-based life (or the "RNA world") and eventually to cellular life based on DNA and proteins. Nucleic acids are large complex molecules that store and convey genetic information, but can also function as enzymes.

While the transfer of sequence information between two different classes of nucleic acid-like molecules-between RNA and DNA, for example-is straightforward because it relies on the one-to-one correspondence of the double helix pairing, transferring catalytic function is significantly more difficult because function cannot be conveyed sequentially. The present study demonstrates that the "evolutionary conversion" of an RNA enzyme to a DNA enzyme with the same function is possible, however, through the acquisition of a few critical mutations.

The study was released in an advance online version of the journal Chemistry & Biology.

Scripps Research Professor Gerald F. Joyce, a member of the Skaggs Institute for Chemical Biology whose laboratory conducted the study, said, "During early life on earth both genetic information and catalytic function were thought to reside only in RNA. In our study, the evolutionary transition from an RNA to a DNA enzyme represents a genuine change, rather than a simple expansion, of the chemical basis for catalytic function. This means that similar evolutionary pathways may exist between other classes of nucleic acid-like molecules. These findings could help answer some fundamental questions concerning the basic structure of life and how it evolved over time."

As Francis Crick, the Nobel laureate who, along with James Watson uncovered the double helix structure of DNA, articulated in 1970, all known organisms operate according to the central dogma of mo
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
27-Mar-2006


Page: 1 2 3

Related biology news :

1. Ewwwww! UCLA anthropologist studies evolutions disgusting side
2. Researchers untangle nature of regressive evolution in cavefish
3. Quiet revolution may herald new RNA therapeutics
4. Modern humans, not Neandertals, may be evolutions odd man out
5. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
6. Mobile DNA part of evolutions toolbox
7. On a flys wing, scientists tally evolutions winners and losses
8. Northeast Sun Grant Institute at Cornell spurs green revolution
9. Scientist converts UK nuclear energy policy
10. Protecting virus offers instant flu protection and converts flu infections into their own vaccines
11. Newly identified enzyme group converts protein into cellular traffic signal

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2020)... ... July 16, 2020 , ... A ... of the Invictus Medical Neoasis™ active noise control device to attenuate typical noises ... the Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and other ...
(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming ... Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. ... what is the most effective way to complete one? Will the study comply ...
(Date:7/4/2020)... ... , ... Aesthetics Biomedical (ABM), a leading aesthetics product development ... the products and treatments developed, but also the dedicated team behind the brands ... built by ABM have received several honors already for 2020, each of which ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... , ... R3 Stem Cell International is now offering patients the opportunity to ... total, patients may choose which extremities they would like treated. , Several studies have ... 2016). At R3 International, umbilical cord tissue is obtained from a lab with a ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has introduced new ... for use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical ... requirements, performance, and cost criteria; especially where solid wire is limited. Typical configurations ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... of the top radiation centers in 16 countries, has reached its 20th anniversary ... is now in routine use at top universities including University of Pennsylvania, University ...
(Date:7/18/2020)... ... , ... After research model surgery and catheter implantation, the long journey of ... beginning of a successful study, while protecting and accessing the catheter or device post-surgery ... Surgery from Envigo in a live webinar on Wednesday, August ...
Breaking Biology Technology:
Cached News: