Activating ATR

NOTE: This research was made available thru advanced online publication.

ATR coordinates the cellular response to DNA damage, both by sensing that damage has occurred, and helping to propagate the intracellular signal to fix it. But how ATR recognizes several disparate forms of DNA damage (ie., UV-induced cross-links, oxidative damage, and polymerase toxins) had remained elusive. Now, Dr. Karlene Cimprich and colleagues have identified how a single-stranded DNA structure can serve as a common intermediate to activate ATR in response to various forms of genotoxic stress. Emphasizing the importance of this finding, Dr. Cimprich explains that "Cells must properly detect and respond to DNA lesions, and this activity is critical for maintaining the integrity of the genome and the prevention of cancer."


Contact: Heather Cosel
Cold Spring Harbor Laboratory

Page: 1

Related biology news :

1. Waters off Washington state only second place in world where glass sponge reefs found
2. Pioneering approach to wastewater treatment earns Stanford engineer the 2007 Stockholm Water Prize
3. Water theory is watertight, researchers say
4. Water Treatment and Reuse -- II
5. Water filtration technique removes dangerous freshwater algae toxins
6. NJIT professor to address Water Industry Conference At Harvard Club about desalinating water
7. Caltechs Emmanuel Candes to receive $500,000 Waterman Award
8. Water management in cells
9. Water quality a major focus of $14 million grant to the University of Arizona
10. Water and the environment
11. National Academy news: Water quality improvement in southwestern Pennsylvania

Post Your Comments:

(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
(Date:6/23/2016)... 2016   EpiBiome , a precision microbiome engineering ... debt financing from Silicon Valley Bank (SVB). The financing ... advance its drug development efforts, as well as purchase ... "SVB has been an incredible strategic partner to us ... bank would provide," said Dr. Aeron Tynes Hammack ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. Hays ... DNA as a Field Application Specialist. , “I am thrilled that Dr. Young ... DNA. “In further expanding our capacity as a scientific integrator, Hays brings a wealth ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
Breaking Biology Technology:
Cached News: