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Activation of microRNA inhibits cancer gene in human cancer cells

tested, was highly induced after treatment with the chromatin-remodeling drugs. Induction of miR-127 resulted in downregulation of BCL6, a known proto-oncogene. Therefore, induction of miR-127 by treatment with chromatin-remodeling drugs may have an anticancer effect.

"Taken together, our results suggest an effect of epigenetic treatment that couples inhibitors of DNA methylation and histone deacetylation to induction of some miRNAs. These miRNAs can potentially regulate expression of target genes that are important in the development and progression of human cancer. Further studies on epigenetic regulation of miRNA expression are necessary, and regulation of miRNA expression by epigenetic treatment may be a novel strategy for prevention or treatment of human cancer," offers Dr. Jones.


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Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
12-Jun-2006


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