HOME >> BIOLOGY >> NEWS
Activation of thermoreceptors mediates raw garlic's burning pungency

The worldwide popularity of garlic as a food ingredient and its therapeutic stature in folklore both stem in part from the distinctive pungency associated with its raw, uncooked state. Researchers this week report that this pungency, manifested as a characteristic mixture of burning and prickling sensations and flavor, can be ascribed largely to the effects of a particular compound and its ability to activate specific protein thermoreceptors in the mouth.

The findings are reported in the May 24 issue of Current Biology by a team led by Ardem Patapoutian of The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation.

Despite garlic's popularity, the compounds responsible for its pungency, as well as the receptors through which we perceive those compounds, have remained unknown. In their new work, the researchers found that raw, but not baked, garlic was capable of eliciting responses from two so-called TRP ("trip") channels, TRPV1 and TRPA1, which belong to a remarkable family of receptors that can be activated by temperature and chemicals. Some TRP channels, including TRPA1 and TRPV1, respond to both temperature and chemical compounds: TRPV1 is known to respond to noxious (painful) heat and to the pungent component of chili peppers, whereas TRPA1 is activated by noxious cold and by pungent compounds found in cinnamon oil, mustard oil, and wintergreen oil. These past findings, as well as the present work, indicate that thermosensitive TRP channels play a key role in the phenomenon of chemesthesis (the somatosensory contribution to the sense of taste), which is experienced, for example, in the heat of chili peppers or the coolness of peppermint. Both TRPV1 and TRPA1 are found in pain-sensing neurons that innervate the mouth and tongue.

The researchers went on to identify the sulfide compound allicin, an unstable chemical found in bruised, cut, or crushed garlic, as the chemical responsible for the activa
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
23-May-2005


Page: 1 2

Related biology news :

1. Activation of microRNA inhibits cancer gene in human cancer cells
2. Vampires beware: Scripps scientists describe molecular basis of raw garlics pungency
3. Bugs expose underground carbon traffic system 10 times more important than fossil fuel burning
4. Cholesterol-regulating protein maintains fat-storage, fat-burning balance
5. Altering steroid receptor genes creates fat burning muscle
6. Arid Australian interior linked to landscape burning by ancient humans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2019)... ... 2019 , ... Orbsen Therapeutics, a biotechnology company focused on ... move its base of operations from the National University of Ireland (NUI) Galway ... in Galway, Ireland. , “With four clinical trials in full swing and the ...
(Date:4/4/2019)... ... April 02, 2019 , ... Researchers from Ambry Genetics ... RNA genetic testing (RGT), as a supplement to DNA genetic testing, improves variant ... poster, is one of 13 presentations at the 2019 American College of Medical ...
(Date:4/1/2019)... ... 2019 , ... uBiome announces the issue of patent number ... Patent and Trademark Office on January 1, 2019 with a priority date of ... Zachary Apte, Dr. Daniel Almonacid, Dr. Jessica Richman, and Dr. Catalina Valdivia, and ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... ... , ... US Capital Global Securities , an affiliate of US Capital ... privately held pharmaceutical company, S1 Biopharma (“S1”). , S1 has a pipeline of drugs ... dysfunction disorder and is ready to begin phase 2b trials. In phase 2a trials, ...
(Date:3/27/2019)... , ... March 26, 2019 , ... A leader in ... cell services to veterinarians across the United States and Canada since 2004. The ... and soft tissue injuries in the dog, cat, and horse. Recently, VetStem ...
(Date:3/19/2019)... ... 2019 , ... The AACR annual conference pulls together a diverse group of ... cancer research. The Visikol team will be at the show at booth #3252 and ... as their digital pathology services . “For AACR this year we are highlighting ...
(Date:3/19/2019)... and BASEL, Switzerland (PRWEB) , ... ... ... Medical Center at Tel HaShomer, the largest hospital in Israel and the ... point-of-care cell-therapy manufacturing using the state-of-the-art Cocoon™ manufacturing platform. The partnership will ...
Breaking Biology Technology:
Cached News: