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Adult neurogenesis newly adult-born neurons are functionally similar to mature neurons

e dynamic manner to the stimulation, suggesting their ability to undergo synaptic plasticity is similar. Next, the researchers looked at GABAergic (inhibitory) inputs from interneurons that connect to the body and dendrites of the hippocampal neurons. Again, they see the responses are similar in frequency, amplitude, and kinetics between the pup-born and adult-born cells.

Having shown that pup-born and adult-born neurons respond to both excitatory and inhibitory inputs in the same way, the researchers next turned their attention to how the two types of cells integrate the signals from the various inputs to produce an action potential, or spike (which leads to the communication of the signal to subsequent neurons). Spiking probability varied among neurons but was not distinguishable between the two cell types, further supporting the earlier indications that adult-born and pup-born neurons function in fundamentally the same way.

Given the functional similarities between adult-born and pup-born neurons, this means that at least some neurons that develop in adult brains can form connections that are indistinguishable from connections formed by neurons that develop early in life--a hopeful finding for those who have set their sights on one day being able to repair damaged or deteriorated brain tissue.


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Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
20-Nov-2006


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