African-American women less likely to undergo genetic testing than white women

There are large racial disparities in the use of genetic testing for breast and ovarian cancer, according to a study in the April 13 issue of JAMA.

Mutations in the genes BRCA1 or BRCA2 confer a significantly increased risk of breast and ovarian cancer, according to background information in the article. Women with a BRCA1/2 mutation have a lifetime breast cancer risk of 50 percent to 85 percent and a lifetime ovarian cancer risk of 14 percent to 40 percent. Testing for mutations in BRCA1/2 can provide individual information about breast and ovarian cancer risk that may affect decisions about prophylactic surgery, chemoprevention, and screening. Although clinical testing for BRCA1/2 mutations became available in 1996, relatively little is known about the determinants of testing use in the general population, including potential racial differences in utilization.

Katrina Armstrong, M.D., M.S.C.E., of the University of Pennsylvania School of Medicine, Philadelphia, and colleagues conducted a study to assess the association between race and use of genetic counseling for BRCA1/2 testing among women at risk of carrying a BRCA1/2 mutation and to evaluate the potential contributions of cancer risk perception and worry, socioeconomic characteristics and attitudes about genetic testing.

The study, conducted from December 1999 to August 2003, included 408 women with a family history of breast or ovarian cancer, of whom 217 underwent genetic counseling for BRCA1/2 testing (cases) and 191 women did not (controls).

The researchers found that "African American women with a family history of breast or ovarian cancer are much less likely [78 percent less likely] to undergo genetic counseling for BRCA1/2 testing than are white women with a family history of breast or ovarian cancer. Furthermore, this racial disparity is not explained by differences in the probability of carrying a BRCA1/2 mutation, socioeconomic status, cancer risk perception and wo

Contact: Olivia Fermano
JAMA and Archives Journals

Page: 1 2 3

Related biology news :

1. New clue why MS affects African-Americans differently than Caucasians
2. Slow wave activity during sleep is lower in African-Americans than Caucasians
3. OSA symptoms more common among African-American women than Caucasians
4. Survey finds perceived risk of recurrence low in African-American breast cancer survivors
5. African-Americans at increased risk for earlier preterm births
6. Missouris African-American mothers more likely to deliver prematurely
7. African-Americans with prostate cancer more likely to have family history of prostate, breast cancer
8. Genetic variant is associated with higher rate of premature delivery in African-American women
9. Faulty cell cycle checkpoints linked to lung cancer risk in African-Americans
10. Breast cancer risk increased for African-Americans with mitochondrial DNA variant
11. NJIT ranked 9th in the nation for graduating African-American engineers

Post Your Comments:

(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces expanded ... of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market for ... fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS estimates ...
(Date:10/11/2017)... ... October 11, 2017 , ... The ... context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. The ... transformative for performing systematic gain-of-function studies. , This complement to loss-of-function studies, ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... 11, 2017 , ... Singh Biotechnology today announced that the ... its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B VHH13 single ... the cell membrane and bind intracellular STAT3 and inhibit its function. Dysregulation of ...
Breaking Biology Technology:
Cached News: