HOME >> BIOLOGY >> NEWS
Aggression-related gene weakens brain's impulse control circuits

A version of a gene previously linked to impulsive violence appears to weaken brain circuits that regulate impulses, emotional memory and thinking in humans, researchers at the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH) have found. Brain scans revealed that people with this version especially males tended to have relatively smaller emotion-related brain structures, a hyperactive alarm center and under-active impulse control circuitry. The study identifies neural mechanisms by which this gene likely contributes to risk for violent and impulsive behavior through effects on the developing brain.

NIMH intramural researchers Andreas Meyer-Lindenberg, M.D., Ph.D, Daniel Weinberger, M.D., and colleagues report on their magnetic resonance imaging (MRI) study online in the Proceedings of the National Academy of Sciences during the week of March 20, 2006.

"These new findings illustrate the breathtaking power of 'imaging genomics' to study the brain's workings in a way that helps us to understand the circuitry underlying diversity in human temperament," said NIH Director Elias A. Zerhouni, M.D., who conducted MRI studies earlier in his career.

"By itself, this gene is likely to contribute only a small amount of risk in interaction with other genetic and psychosocial influences; it won't make people violent," explained Meyer-Lindenberg. "But by studying its effects in a large sample of normal people, we were able to see how this gene variant biases the brain toward impulsive, aggressive behavior."

The gene is one of two common versions that code for the enzyme monoamine oxydase-A (MAO-A), which breaks down key mood-regulating chemical messengers, most notably serotonin. The previously identified violence-related, or L, version, contains a different number of repeating sequences in its genetic code than the other version (H), likely resulting in lower enzyme activity and hence higher levels of seroton
'"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
20-Mar-2006


Page: 1 2 3

Related biology news :

1. Elevated CO2 in atmosphere weakens defenses of soybeans to herbivores
2. Epilepsy drug eases symptoms of inherited disorder that weakens muscles
3. Preconditioning helps protect brains blood vessels from stroke
4. New study examines brains own marijuana
5. Study shows response to financial loss parallels brains processing of pain
6. Impulsiveness linked to activity in brains reward center
7. Its in your head: The brains own globin defends you from shock and stroke
8. Scientists identify switch for brains natural anti-oxidant defense
9. Food or its expectation sparks brains hunger centers
10. Study offers clues to brains protective mechanisms against alcoholism
11. Seeing beyond the gray areas: New tool uncovers the importance of the brains white matter

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ... appointment of independent Directors Mr. Robin D. Richards ... Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive ... their guidance and benefiting from their considerable expertise as we ...
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... Foundation President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO ... ASTER Labs ), Inc. has been selected for membership in ARCS Alumni ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is ... and 8th June 2018 in San Francisco, CA. The Summit brings together current and ... distinguished CEOs, board directors and government officials from around the world to address key ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
Breaking Biology Technology:
Cached News: