HOME >> BIOLOGY >> NEWS
Aggressive therapy best for certain AML patients

COLUMBUS , Ohio A new study suggests that acute leukemia patients whose cancer cells show a genetic change that usually predicts a swift return of the disease following remission may remain disease-free longer when given aggressive therapy.

The findings apply to people with acute myeloid leukemia (AML) whose cancer cells have normal-looking chromosomes and a gene mutation called MLL-PTD.

Typically, these AML patients responded poorly following treatment with older standard therapies, often relapsing within a year. Of AML patients with normal chromosomes who lack the mutation, on the other hand, four in 10 are cured.

The new study suggests that treating patients who have the mutation with an aggressive therapy such as an autologous stem cell transplant while they are in remission might significantly extend their disease-free survival.

An autologous transplant uses stem cells taken from the patient's own blood.

The research was led by investigators at the Ohio State University Comprehensive Cancer Center. It is part of a larger study sponsored by the Cancer and Leukemia Group B (CALGB), a clinical cooperative group composed of oncologists from academic medical centers and community hospitals across the nation.

The findings were published in a recent issue of the journal Blood.

Our data is the first to show that AML patients with normal-looking chromosomes and this mutation do as well when treated aggressively as patients who don't have the mutation, says principal investigator Clara D. Bloomfield, professor of internal medicine and an internationally known AML specialist.

About 13,400 new cases of AML are expected this year, and about half will have cancer cells with chromosomes that show distinctive damage. The nature of that damage helps doctors determine a patient's therapy and estimate the patient's prognosis.

The remaining AML cases have cancer cells with normal
'"/>

Contact: Eileen Scahill
Eileen.Scahill@osumc.edu
614-293-2092
Ohio State University
1-Aug-2007


Page: 1 2

Related biology news :

1. Aggressive subtype of breast cancer displays misbehavior of X chromosomes
2. Aggressive aquatic species invading Great Lakes
3. Testosterone replacement therapy: How safe for aging men?
4. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
5. Under magnetic force, nanoparticles may deliver gene therapy
6. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
7. Stem cell therapy rescues motor neurons in ALS model
8. Study identifies new gene therapy tools for inherited blindness
9. Breast cancer and hormone therapy -- A looking-glass mirror?
10. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
11. Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... ... ... In an upcoming episode scheduled for the fall of 2020, Advancements with ... Check local listings for more info. , Today, the majority of testing is performed ... throughout the country. Results are then available several days later. Now, in an effort ...
(Date:6/23/2020)... MILTON KEYNES, England (PRWEB) , ... June 23, ... ... operations in Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and ... rapid response project to support testing operations in the fight against the COVID-19 ...
(Date:6/23/2020)... ... ... In its June 22 online post, business and technology news platform Superb Crew ... and director of stem cell biotechnology company Asymmetrex . Superb Crew decided to ... 5 it would begin offering free tissue stem cell counting at its ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 09, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology ... R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will ... SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine at the ...
(Date:7/1/2020)... N.C. (PRWEB) , ... June 29, 2020 , ... ... reported year to date growth of 40% in 2020, despite many obstacles created ... technology, MedShift aims to increase revenue for its partnered medical practices and medical ...
(Date:6/28/2020)... NIGUEL, Calif. (PRWEB) , ... June 25, 2020 , ... ... announced the launch of Safe Space™ for businesses of all types to ensure cleanliness, ... 3D LiDAR. , A Safe Space™ enabled business will provide a health ...
(Date:6/28/2020)... , ... June 26, 2020 , ... ... representing security solutions providers, today announced its strong opposition to the recently introduced ... would impose a blanket ban on most federal use of nearly all biometric ...
Breaking Biology Technology:
Cached News: