HOME >> BIOLOGY >> NEWS
Ago2 and hematopoiesis

Argonaute 2 (Ago2) is unique among its family: It is the only one of the four mammalian Argonaute proteins that exhibits endonuclease slicer activity (facilitation of miRNA-guided cleavage of target mRNA).

However, as Drs. Donal OCarroll and Alexander Tarakhovsky (The Rockefeller Institute) report in an upcoming issue of G&D, Ago2s defining characteristic is surprisingly non-essential for its role in hematopoiesis and miRNA biogenesis.

An advanced version of their paper will be posted online at www.genesdev.org.

Drs. OCarroll, Tarakhovsky and colleagues generated transgenic mice harboring mutated versions of Ago2 in their bone marrow. The researchers found that Ago2 is, indeed, quite necessary for normal blood cell development. Its endonulcease activity, however, is not.

The scientists were able to restore erythropoiesis in Ago2-deficient mice by expressing a mutated version of Ago2 that lacks its endonuclease activity, thereby demonstrating that the role of Ago2 in the hematopoietic system is independent of its slicer activity. Rather, Dr. OCarroll and colleagues found that Ago2 regulates miRNA biogenesis in blood cells.

Our results suggest that the effector function of miRNA in somatic cells relies mostly on translational control of gene expression rather than on destruction of the mRNA targets. This finding may force rethinking of current strategies for the identification of miRNA targets in cells with individual miRNA overexpression or deficiency, explains Dr. Tarakhovsky.


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
11-Jul-2007


Page: 1

Related biology news :

1. Bursts of waves drive immune system soldiers toward invaders
2. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
3. Link between immune system and mammary gland could shed new light on breast cancer
4. Researchers discover method for identifying how cancer evades the immune system
5. Invertebrate immune systems are anything but simple, conference finds
6. Mucosal-surface immune function discoveries could boost vaccine research
7. LIAI researchers identify a potential role for retinoic acid in autoimmune and inflammatory diseases
8. UCLA researchers discover novel pathway that may promote immune system balance
9. Pregnant moms exposure to flu vaccine kick-starts fetal immune system
10. Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism
11. Natural immune-control system may aid treatment of autoimmune disease and tissue rejection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... ARLINGTON, Va. , June 30, 2017 /PRNewswire-USNewswire/ ... a leading developer and supplier of face and ... the ATA Featured Product provider program. ... created an innovative way to monitor a driver,s ... benefit greatly from being able to detect fatigue ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... States multicenter, prospective clinical study that demonstrates the accuracy of the FebriDx® ... identifying clinically significant acute bacterial and viral respiratory tract infections by testing ...
(Date:10/12/2017)... ... 12, 2017 , ... AMRI, a global contract research, development ... patient outcomes and quality of life, will now be offering its impurity solutions ... new regulatory requirements for all new drug products, including the finalization of ICH ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief ... ), Inc. has been selected for membership in ARCS Alumni Hall of ...
(Date:10/11/2017)... ... 11, 2017 , ... Personal eye wash is a basic first aid supply for any work ... which eye do you rinse first if a dangerous substance enters both eyes? It’s one ... with its unique dual eye piece. , “Whether its dirt and debris, or an ...
Breaking Biology Technology:
Cached News: