Algae provide new clues to cancer

A microscopic green alga helped scientists at the Salk Institute for Biological Studies identify a novel function for the retinoblastoma protein (RB), which is known for its role as a tumor suppressor in mammalian cells. By coupling cell size with cell division, RB ensures that cells stay within an optimal size range.

Their findings, which will be published in the October 13 online edition of PLoS Genetics, show that RB blocks cells from dividing before they reach a minimum size and could provide new insights into the origins of cancer.

"Being the right size is very important for cells because their physiology changes quite dramatically when the surface-to-volume ratio changes," explains senior author James Umen, Ph.D., an assistant professor and Hearst Endowment Chair in Salk's Plant Biology Laboratory. "The human body is composed of trillions of cells, each of which must coordinate its growth and division in order to maintain size equilibrium," he adds.

This process is very tightly regulated and any given cell type will always stay within a very narrow size range, but the means by which cell size is determined remain mysterious. In proliferating cells, control mechanisms termed checkpoints are thought to prevent cells from dividing until they reach a specific size, but the nature of the checkpoints has proved difficult to dissect.

Understanding how cells balance the opposing processes of growth and division in order to achieve size control is more than just a fascinating intellectual pursuit for cell biologists: loss of size control is a hallmark of cancer cells, which exhibit severe defects in regulating growth and division.

"In mammalian cells it is very hard to separate size control from cell cycle control because it is very easy to mess up cell size as an indirect consequence of manipulating cell cycle rates," says Umen.

The tiny single-celled alga Chlamydomonas reinhardtii provided a model orga

Contact: Gina Kirchweger
858-453-4100 x1340
Salk Institute

Page: 1 2 3

Related biology news :

1. Algae toxin identification unravels fish-kill mystery
2. Algaes protein tails create motion and aid munching
3. New study suggests Concord grape juice may provide protection against breast cancer
4. Female gender provides an advantage in renal diseases
5. Forecasting system provides flood warnings to vulnerable residents of Bangladesh
6. Discovery of new protein could provide new understanding of male fertility
7. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
8. Genomics study provides insight into the evolution of unique human traits
9. Expert to provide update after worst tomato virus hits California
10. Study provides new data about the laws governing embryo development in organisms
11. Sea anemone genome provides new view of our multi-celled ancestors

Post Your Comments:

(Date:6/1/2016)... , June 1, 2016 ... in Election Administration and Criminal Identification to Boost Global ... a recently released TechSci Research report, " Global Biometrics ... Region, Competition Forecast and Opportunities, 2011 - 2021", the ... billion by 2021, on account of growing security concerns ...
(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... the Pennsylvania Convention Center and will showcase its product’s latest features from June ... be presenting a scientific poster on Disrupting Clinical Trials in The Cloud during ...
(Date:6/23/2016)... , June 22, 2016  Amgen (NASDAQ: ... of the QB3@953 life sciences incubator to ... health. The shared laboratory space at QB3@953 was created ... a key obstacle for many early stage organizations - ... of the sponsorship, Amgen launched two "Amgen Golden Ticket" ...
(Date:6/22/2016)... , June 22, 2016 Research and ... Global Markets" report to their offering. ... billion in 2014 from $29.3 billion in 2013. The market is ... of 13.8% from 2015 to 2020, increasing from $50.6 billion in ... projected product forecasts during the forecast period (2015 to 2020) are ...
Breaking Biology Technology:
Cached News: