HOME >> BIOLOGY >> NEWS
Alzheimer's, Parkinson's, type 2 diabetes similar at molecular level

Alzheimers disease, Parkinsons disease, type II diabetes, the human version of mad cow disease and other degenerative diseases are more closely related at the molecular level than many scientists realized, an international team of chemists and molecular biologists reported April 29 in the online version of the journal Nature (print version to follow).

Harmful rope-like structures known as amyloid fibrils, which are linked protein molecules that form in the brains of patients with these diseases, contain a stack of water-tight "molecular zippers," the scientists report.

"We have shown that the fibrils have a common atomic-level structure," said David Eisenberg, director of the UCLADepartment of Energy Institute of Genomics and Proteomics, a Howard Hughes Medical Institute investigator and a member of the research team. "All of these diseases are similar at the molecular level; all of them have a dry steric zipper. With each disease, a different protein transforms into amyloid fibrils, but the proteins are very similar at the atomic level."

The research, while still preliminary, could help scientists develop tools for diagnosing these diseases and, potentially, for treating them through "structure-based drug design," said Eisenberg, a UCLA professor of chemistry and molecular biology.

The researchers, including scientists with the European Synchrotron Radiation Facility in Grenoble, France, report 11 new three-dimensional atomic protein structures, including those for both of the main proteins that form amyloid fibrils in Alzheimers disease.

"It has been a joy to see so many new structures," said Michael Sawaya, a research scientist with UCLA and the Howard Hughes Medical Institute and a member of the team. "Each one is like a Christmas present. Now that we have so many of these that we can classify, I am thrilled to see each three-dimensional arrangement of atoms, what the structural similarities and differences ar
'"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
30-Apr-2007


Page: 1 2 3 4

Related biology news :

1. New studies on Alzheimers, autism, nicotine addiction and depression highlight annual meeting
2. A better tool to study role of iron in Alzheimers, Parkinsons
3. SNM experts focus on advances in molecular imaging for cancer, addiction, Alzheimers, heart disease
4. Molecular zipper may hold important clues to Alzheimers, Parkinsons and mad cow disease
5. UCI researchers identify trigger for onset of Alzheimers, aiding search for new therapies
6. UC San Diego supercomputer simulations may pinpoint causes of Parkinsons, Alzheimers diseases
7. Key stress protein linked to toxicities responsible for Parkinsons, Alzheimers
8. Discoveries may advance stem cell therapy for Parkinsons, cancer patients
9. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
10. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
11. Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 19, 2020 , ... “How can we ... dedicated to Salivary Bioscience for more than twenty years. Together with Douglas Granger, ... " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven ...
(Date:8/12/2020)... ... 12, 2020 , ... Mosio recently announced its newly updated ... agencies of all sizes. With a focus on tracking symptoms and monitoring outbreaks ... care, Mosio helps public health departments automate communications and provide more personalized care ...
(Date:8/3/2020)... ... August 03, 2020 , ... Accumen Inc. is helping ... equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , ... for more than 10 years. Early in the COVID-19 crisis, we identified supply ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , the leading platform for ... Board (SAB) to research the medical potential of terpenes and the potential entourage ... terpenes. The board is focused on expanding the recently launched line of effects-based terpenes ...
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a highly regarded ... on the purchase of greenfield for a new, expanded manufacturing facility. The site ... acres in the initial acquisition, with an option to purchase an additional 21 ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, ... that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... or two switches in a push-pull configuration; yielding fast fall time for a ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... sciences industry, today announced the release of its signature product called Beacon ... Liaisons (MSLs) and other field medical professionals. , Beacon helps MSLs ...
Breaking Biology Technology:
Cached News: