American research finds twins more likely to have premature menopause

than for later menopause.

"We haven't been able to make much progress towards understanding the mechanism in identical twins because of lack of suitable animal models. But, there are two possibilities that we may be able to check. First, discordant ovaries could arise if early post-implantation embryos split unequally during the critical period when progenitor germ cells are forming. Then a subnormal number of follicles might form in one twin. Second, there could be competition in the uterus and the stress might encourage abnormalities in the ways the genes needed to make eggs are expressed in the ovaries of each twin. We are not looking for mutations in the DNA sequence, but gene switches, a topic called epigenetics."

Dr Gosden said that while the great majority of identical and non-identical twins can expect to reach menopause at a similar age to singletons there were clinical implications for a twin with POF whose sibling is still fertile.

"The first option is of ooctye donation for both identical and non-identical twins. For identical twins, in addition, we now have the possibility of ovarian tissue grafting. That might even be considered in some rare cases for non-identical twins if there is a good tissue match.

"This is an important development as, although proportionately rare, the numbers of cases could be substantial in large countries. In the USA, for example, there are 150,000 identical twin pairs in the 20 to 40 age bracket. About 6,000 individuals (4%) will have POF before they are 40 and the data predict a substantial proportion of these will have a sister with a larger ovarian reserve and a likely later menopause."


Contact: Margaret Willson
European Society for Human Reproduction and Embryology

Page: 1 2 3

Related biology news :

1. American Chemical Societys Weekly PressPac -- Aug. 8, 2007
2. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
3. American Chemical Society meets Aug. 19-23 in Boston
4. American Chemical Societys Weekly PressPac -- Aug. 1, 2007
5. American buffalo slaughter fueled by international trade
6. American Chemical Societys Weekly PressPac -- July 25, 2007
7. American Chemical Societys Weekly PressPac -- July 18, 2007
8. American Chemical Societys Weekly PressPac -- July 11, 2007
9. Tips from the Journals of the American Society for Microbiology
10. Wiley extends publishing partnership with the American Institute of Chemical Engineers
11. Highlights from the July 2007 Journal of the American Dietetic Association

Post Your Comments:
(Date:9/10/2015)... 10, 2015 Report Details ... Selling Opportunities and Revenue Prospects to Help You ... biologics, especially new drug classes? Get the latest ... with exclusive market data and industry knowledge, benefitting ... results, opportunities and sales predictions. Visiongain,s new ...
(Date:9/8/2015)... Sept. 8, 2015   TREW Marketing and ... survey, Smart Marketing for Engineers TM : Content ... professionals reveals insightful findings about engineers, preferences for online ... content engineers most value and trust, and where they ... targeting technical audiences grapple with how to best implement ...
(Date:9/1/2015)... Sept. 1, 2015  Automation and pre-processing are ... passenger screening. This is the first step toward ... will become unintrusive. An assortment of portal scanners, ... background investigations will transform the passenger screening process. ... Global Airport Passenger Screening Market ( ...
Breaking Biology News(10 mins):
(Date:10/8/2015)...  Today the Wyss Institute for Biologically Inspired Engineering ... company Opsonix Inc. The announcement follows a ... Technology Development (OTD) and Opsonix Inc. enabling the ... use. --> --> ... every year in the U.S. — more than prostate ...
(Date:10/7/2015)... , October 8, 2015 ... Medical biotechnology accounts for largest bioinformatics ... bioinformatics in drug discovery and development process ... http://www.marketreportshub.com/bioinformatics-industry-research-2020-marketsandmarkets.html . --> ... On the basis of applications, the bioinformatics ...
(Date:10/7/2015)... , Oct. 7, 2015  ContraVir Pharmaceuticals, Inc. (Nasdaq: ... company focused on the development and commercialization of targeted ... public offering of 5,000,000 shares of its common stock ... the Company,s common stock at a fixed combined price ... stock and warrants will be issued separately.  The warrants ...
(Date:10/7/2015)... ... October 07, 2015 , ... ... titled Smart Nanostructured Coatings to provide a comprehensive overview of the innovations in ... webinar at http://bit.do/smart-coatings . This webinar will be given by Professor Roberto ...
Breaking Biology Technology:
Cached News: