Amphetamine-related drugs ameliorate symptoms of Parkinson's

The debilitating effects of Parkinson's disease are well known: muscle rigidity, impaired movement, and the uncontrollable shaking that makes even the most mundane activity a challenge. The symptoms result from a progressive deterioration of neurons, found in the midbrain, that produce dopamine. With no cure on the horizon, the most common treatment involves administration of the dopamine precursor, L-DOPA, usually in pill form. Though symptoms subside at first, this treatment is rendered ineffective over time.

In a new study reported in the open-access journal PLoS Biology, Tatyana Sotnikova and colleagues from Duke University create a mouse model that recapitulates many of the symptoms of Parkinson's disease and use it to screen potential therapeutic drugs. By eliminating the dopamine transporter - the protein responsible for recycling the chemical into neurons - in mice, the authors reduced dopamine levels in the midbrain by 20-fold. In addition, chemically inhibiting dopamine production in these mice resulted in essentially unmeasurable levels of the neurotransmitter, since it could now neither be produced at normal levels nor be recycled.

The authors tested a number of drugs at various doses and found that in addition to L-DOPA-related treatments, drugs related to amphetamine were effective in ameliorating muscle rigidity, tremor, and impaired movement in these mice. Most effective was methylenedioxymethamphetamine HCl (MDMA), commonly known as ecstasy. It has been shown that amphetamines can trigger release of neurotransmitters such as dopamine, serotonin, and norepinephrine and cause sudden bursts in neurotransmission, leading to a feeling of alertness, increased muscular activity, and reduced fatigue. This study, however, shows that treating mice with MDMA does not increase dopamine levels; furthermore, treating the mice with drugs related to serotonin or norepinephrine did not ameliorate the disease's sympto

Contact: Paul Ocampo
Public Library of Science

Page: 1 2

Related biology news :

1. MIT model could predict cells response to drugs
2. New target for HIV/AIDS drugs and vaccine discovered
3. Modified mushrooms may yield human drugs
4. UGR researchers design an alternative to blood test to detect drugs in the body
5. Could fungal collection hold the key to new life-saving drugs?
6. Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
7. Scientists develop new drugs to fight colon and breast cancer more effectively
8. Anti-inflammatory drugs interact with HRT, and more
9. Generic biologic drugs unlikely to offer significant savings
10. Stem cells provide new tool for studying disease and identifying ALS drugs
11. Enhancing chemotherapys efficacy: New agent has synergistic effect with standard drugs

Post Your Comments:

(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... STACS DNA Inc., the sample tracking software company, today announced ... has joined STACS DNA as a Field Application Specialist. , “I am thrilled ... COO of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest features ... will also be presenting a scientific poster on Disrupting Clinical Trials in The ...
Breaking Biology Technology:
Cached News: