HOME >> BIOLOGY >> NEWS
Amphetamines reverse Parkinson's disease symptoms in mice

Durham, N.C. Amphetamines, including the drug popularly known as Ecstasy, can reverse the symptoms of Parkinson's disease in mice with an acute form of the condition, according to new research at Duke University Medical Center.

The researchers caution that the findings in animals do not suggest Parkinson's disease patients should find relief by taking amphetamines, which are drugs of abuse with many dangerous side effects. The findings rather indicate that drugs with similar chemical attributes might offer useful alternatives to current therapies, the researchers said.

The new study also shows that amphetamines -- normally thought to act by increasing dopamine concentrations in the brain - correct the behavioral abnormalities associated with Parkinson's in mice devoid of the brain messenger. Dopamine normally acts on dopamine receptors - protein switches on the surface of neurons -- to stimulate brain processes that affect movement, emotion, pleasure and mood.

Parkinson's disease stems from the degeneration of neurons in a brain region that controls movement. That degeneration, in turn, leads to a shortage of the chemical messenger dopamine. The finding that amphetamines can alter movement independently of dopamine opens up new directions in the search for prospective anti-Parkinsonian drugs, the researchers said.

The researchers, led by James B. Duke professor of cell biology Marc Caron, Ph.D. and Assistant Research Professor Raul Gainetdinov, M.D., Ph.D., of Duke, made the discovery after testing the utility of more than 60 compounds for reversing Parkinson's symptoms in a mouse model of the disease. Developed by the Duke team, the mice lack detectable brain levels of dopamine and experience essentially all the symptoms of Parkinson's disease for several hours before recovering their normal behavior. Caron is also a researcher of the Duke Institute for Genome Sciences & Policy.

The team reports its findings in the August 20
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-4148
Duke University Medical Center
1-Aug-2005


Page: 1 2 3 4

Related biology news :

1. MIT researchers reverse symptoms in mice of leading inherited cause of mental retardation
2. Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model
3. Jefferson scientists use gene therapy to reverse heart failure in animals
4. Exercise reverses aging in human skeletal muscle
5. Hyaluronate reverses skin atrophy
6. Changing length of days reverses how estrogen affects aggressiveness in mice
7. Early family experience can reverse the effects of genes, UCLA psychologists report
8. Scientists reverse evolution
9. UF scientists reverse muscle contractions in mouse model of muscular dystrophy
10. Researchers reverse Parkinsons symptoms in animal models
11. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 02, 2020 , ... ... a publication detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to ... in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the ...
(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode scheduled for the fall ... Care Testing solutions (POCT). Check local listings for more info. , Today, the majority ... are shipped to labs throughout the country. Results are then available several days later. ...
(Date:6/23/2020)... ... June 22, 2020 , ... The field of quantitation of ... assays (LBA) have dominated this area. However, the use of mass spectrometry in this ... now necessitates the question “How do you choose which approach to use (LBA or ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and ... can drive one or two switches in a push-pull configuration; yielding fast fall ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the ... the history of eSource, the reasons it did not take off as quickly as ... source, the industry is moving towards capturing data electronically for clinical trials and then ...
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information ... live webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). ... Specifically, for medical devices, the NMPA has departments dealing with medical device registration (pre-market ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... the early detection and prevention of high-burden diseases, and Centric Consulting, a business ... healthcare organizations to utilize existing data in order to identify and prioritize patients ...
Breaking Biology Technology:
Cached News: