HOME >> BIOLOGY >> NEWS
Amphetamines reverse Parkinson's disease symptoms in mice

s included severely impaired movement, rigidity and tremor. When treated with L-DOPA, the symptoms disappeared as the animals resumed normal movement.

Surprisingly, the researchers reported, treating mice lacking dopamine with high doses of amphetamine derivatives including methamphetamine and MDMA, otherwise known as Ecstasy reversed those symptoms. Ecstasy was most effective at counteracting the manifestations of Parkinson's symptoms in the mice, with the beneficial effects becoming more pronounced with increasing dose.

The researchers also report that low doses of amphetamines could, when combined with L-DOPA, potentiate minimally effective doses of L-DOPA in the mice. This could have important considerations in reducing some of the side effects of current therapy.

"The locomotor stimulating effect of amphetamine and its derivatives are classically thought to result from a massive flood of dopamine," said Sotnikova. "However, the mice have only a tiny fraction of dopamine, which cannot be recycled, precluding a rise in dopamine as the possible mechanism.

"Taken together, the findings indicate that Ecstasy can improve movement control independently of dopamine and, most importantly provide evidence that drug activation of other neuronal pathways may be sufficient to restore movement even in the virtual absence of dopamine neurotransmission," she added.

Amphetamines might reverse the animal's symptoms through their effects on a different group of receptors called trace amine receptors, the researchers suggested. Recent evidence showed that amphetamines act on trace amine receptors in addition to dopamine transmission, yet little is known about their physiological role in mammals.

The current findings are particularly promising given the severity of symptoms in the mice completely lacking dopamine, said Gainetdinov. "We think that this new animal model provides a much more stringent test for potential drugs that migh
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-4148
Duke University Medical Center
1-Aug-2005


Page: 1 2 3 4

Related biology news :

1. MIT researchers reverse symptoms in mice of leading inherited cause of mental retardation
2. Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model
3. Jefferson scientists use gene therapy to reverse heart failure in animals
4. Exercise reverses aging in human skeletal muscle
5. Hyaluronate reverses skin atrophy
6. Changing length of days reverses how estrogen affects aggressiveness in mice
7. Early family experience can reverse the effects of genes, UCLA psychologists report
8. Scientists reverse evolution
9. UF scientists reverse muscle contractions in mouse model of muscular dystrophy
10. Researchers reverse Parkinsons symptoms in animal models
11. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: