HOME >> BIOLOGY >> NEWS
An insecure role for Securin in chromosome segregation

A critical aspect of cell division, or mitosis, is that the progeny cells must receive the full complement of chromosomes. Failure of this mechanism, which sometimes happens in cancer cells, leads to rampant chromosome loss and mutations that encourage proliferation and increase instability. Understanding how normal cells unerringly transmit a full chromosome set to their daughters has long been an important part of the fight against cancer.

In a new study published online in the open-access journal PLoS Biology, Katrin Pfleghaar, Michael Speicher, and colleagues reinvestigate the cell's ability to undergo mitosis when missing a key protein, securin. Securin is a chaperone protein that regulates an enzyme that initiates the segregation of the sister chromatids during mitosis. They found that, contrary to previous reports, human cells devoid of the securin protein, which initially suffer widespread chromosome losses, can actually recover after a certain time has passed. In fact, cells with abnormal mitoses and chromosome counts became rarer until, after a few weeks, the cells appeared indistinguishable from their relatives with an intact securin gene. Pfleghaar and her colleagues speculate that securin normally plays an important role in mitoses, but that in its absence, cells tap into compensatory mechanisms to restore proper chromosome segregation.

The implications for cancer treatment are potentially great, as mathematical models of cancer growth do not usually include the possibility that cell populations might recover from chromosomal instability. In addition, such recovery from securin loss, like that seen here, might interfere with therapies that aim to kill cancer cells by exacerbating their chromosome losses.


'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
28-Nov-2005


Page: 1

Related biology news :

1. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
2. Double identities lie behind chromosome disorders
3. St. Jude study yields secrets of chromosome movement
4. Physicist cracks womens random but always lucky choice of X chromosome
5. Researchers shed light on shrinking of chromosomes
6. Researchers attach genes to minichromosomes in maize
7. Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
8. New technique will produce a better chromosome map
9. Short chromosomes put cancer cells in forced rest
10. Shortening chromosomes cause for earlier cancer onset in families with rare syndrome
11. The pull of bacterial chromosome segregation

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: insecure role for Securin chromosome segregation

(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a leading ... services, and Morpho, a leading supplier of biometric ... produce the market,s most advanced biometrically-enabled time clock, ... NXG time clock is setting a bold, new ... data for the small and mid-size employer. When ...
(Date:4/2/2015)... Germany , April 2, 2015 ... fingerprint tests DERMALOG by far outperforms the strongest ... always maintaining high accuracy, the system is capable ... Hence, the speed proves up to be ten ... faster than its runner-up performance.      ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
(Date:5/27/2015)... , May 27, 2015  Tikcro Technologies Ltd. ... ended March 31, 2015. Aviv ... we continued pre-clinical work to generate functional specific antibodies, ... early stage, we are encouraged by the development progress. ... as new antibodies which modulate immune checkpoints gain clinical ...
(Date:5/27/2015)... Calif. , May 27, 2015  CytomX, ... treatment of cancer, today announced the appointments of ... and Cynthia Ladd as senior vice ... Goeltz was chief financial officer of Onyx Pharmaceuticals, ... an independent consultant and legal counsel to several ...
(Date:5/27/2015)... THOUSAND OAKS, Calif. , May 27, 2015 /PRNewswire/ ... company, has been awarded a U.S. patent for a ... gene in areas such as research, product development and ... useful in regulating key biosynthetic processes that are the ... to offer other seed companies a commercial license to ...
(Date:5/27/2015)... Madison, NJ (PRWEB) May 27, 2015 ... for evaluating the impact of regulation on medical innovation, ... Centered Innovation (iPCI) of Fairleigh Dickinson University’s ( ... inaugural MI3 Alert pertains to new FDA ... Senate proposal for accelerating the approval of certain medical ...
Breaking Biology Technology:Tikcro Technologies Reports First Quarter 2015 Results 2Tikcro Technologies Reports First Quarter 2015 Results 3CytomX Expands Executive Leadership Team 2CytomX Expands Executive Leadership Team 3Ceres Awarded Patent for Innovation in Soybean 2Ceres Awarded Patent for Innovation in Soybean 3Medical Innovation Impact Index Launched at Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) under the Rothman Institute 2
Cached News: