HOME >> BIOLOGY >> NEWS
An insecure role for Securin in chromosome segregation

A critical aspect of cell division, or mitosis, is that the progeny cells must receive the full complement of chromosomes. Failure of this mechanism, which sometimes happens in cancer cells, leads to rampant chromosome loss and mutations that encourage proliferation and increase instability. Understanding how normal cells unerringly transmit a full chromosome set to their daughters has long been an important part of the fight against cancer.

In a new study published online in the open-access journal PLoS Biology, Katrin Pfleghaar, Michael Speicher, and colleagues reinvestigate the cell's ability to undergo mitosis when missing a key protein, securin. Securin is a chaperone protein that regulates an enzyme that initiates the segregation of the sister chromatids during mitosis. They found that, contrary to previous reports, human cells devoid of the securin protein, which initially suffer widespread chromosome losses, can actually recover after a certain time has passed. In fact, cells with abnormal mitoses and chromosome counts became rarer until, after a few weeks, the cells appeared indistinguishable from their relatives with an intact securin gene. Pfleghaar and her colleagues speculate that securin normally plays an important role in mitoses, but that in its absence, cells tap into compensatory mechanisms to restore proper chromosome segregation.

The implications for cancer treatment are potentially great, as mathematical models of cancer growth do not usually include the possibility that cell populations might recover from chromosomal instability. In addition, such recovery from securin loss, like that seen here, might interfere with therapies that aim to kill cancer cells by exacerbating their chromosome losses.


'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
28-Nov-2005


Page: 1

Related biology news :

1. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
2. Double identities lie behind chromosome disorders
3. St. Jude study yields secrets of chromosome movement
4. Physicist cracks womens random but always lucky choice of X chromosome
5. Researchers shed light on shrinking of chromosomes
6. Researchers attach genes to minichromosomes in maize
7. Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
8. New technique will produce a better chromosome map
9. Short chromosomes put cancer cells in forced rest
10. Shortening chromosomes cause for earlier cancer onset in families with rare syndrome
11. The pull of bacterial chromosome segregation

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: insecure role for Securin chromosome segregation

(Date:10/14/2014)... – Like discriminating thieves, prostate cancer tumors scavenge and ... body. But such avarice may be a fatal weakness. ... way to kill prostate cancer cells by delivering a ... destroys the diseased cells brimming with the mineral, leaving ... two drugs already commercially available for other uses, could ...
(Date:10/14/2014)... years since T. rex took its last ... is breathing life back into dinosaurs using high-powered computer ... has important implications for how dinosaurs used their noses ... of smell and cool their brains. , "Dinosaurs ... Jason Bourke, lead author of the new study published ...
(Date:10/14/2014)... One of the planet,s leading questions is how to ... increasingly variable climate. The Food and Agriculture Organization of ... 70% over the next 40 years to feed a ... of the necessary rise in food production. Plants—grains, ... by supporting livestock. Current research must tap into ...
Breaking Biology News(10 mins):Prostate cancer's penchant for copper may be a fatal flaw 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
(Date:10/22/2014)... and HONG KONG , Oct. 22, ... therapeutics enterprise, announced today that rare disease expert ... vice president, research. Dr. McKew brings more than two ... positions at the National Institutes of Health, Wyeth Research ... Wyeth). Dr. McKew will lead aTyr,s efforts to expand and ...
(Date:10/20/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") ... orders to $5.8 million and provides a good start to Q4.  ... North America and one in the Middle ... at record levels," said Peter Bruijns , President & CEO. ... of Q3 than they have been for any complete year since ...
(Date:10/20/2014)... Rochelle, Virginia (PRWEB) October 20, 2014 ... of NDA Partners LLC, announced today that Ellen ... and legal support for the pharmaceutical industry, has ... and manager of its legal services practice. ... reports and expert witness and testimony, to top ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and ... and forecast of revenue. , Browse through the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bromine market, and is ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile ...
Breaking Biology Technology:aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
Cached News: