HOME >> BIOLOGY >> NEWS
An insecure role for Securin in chromosome segregation

A critical aspect of cell division, or mitosis, is that the progeny cells must receive the full complement of chromosomes. Failure of this mechanism, which sometimes happens in cancer cells, leads to rampant chromosome loss and mutations that encourage proliferation and increase instability. Understanding how normal cells unerringly transmit a full chromosome set to their daughters has long been an important part of the fight against cancer.

In a new study published online in the open-access journal PLoS Biology, Katrin Pfleghaar, Michael Speicher, and colleagues reinvestigate the cell's ability to undergo mitosis when missing a key protein, securin. Securin is a chaperone protein that regulates an enzyme that initiates the segregation of the sister chromatids during mitosis. They found that, contrary to previous reports, human cells devoid of the securin protein, which initially suffer widespread chromosome losses, can actually recover after a certain time has passed. In fact, cells with abnormal mitoses and chromosome counts became rarer until, after a few weeks, the cells appeared indistinguishable from their relatives with an intact securin gene. Pfleghaar and her colleagues speculate that securin normally plays an important role in mitoses, but that in its absence, cells tap into compensatory mechanisms to restore proper chromosome segregation.

The implications for cancer treatment are potentially great, as mathematical models of cancer growth do not usually include the possibility that cell populations might recover from chromosomal instability. In addition, such recovery from securin loss, like that seen here, might interfere with therapies that aim to kill cancer cells by exacerbating their chromosome losses.


'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
28-Nov-2005


Page: 1

Related biology news :

1. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
2. Double identities lie behind chromosome disorders
3. St. Jude study yields secrets of chromosome movement
4. Physicist cracks womens random but always lucky choice of X chromosome
5. Researchers shed light on shrinking of chromosomes
6. Researchers attach genes to minichromosomes in maize
7. Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
8. New technique will produce a better chromosome map
9. Short chromosomes put cancer cells in forced rest
10. Shortening chromosomes cause for earlier cancer onset in families with rare syndrome
11. The pull of bacterial chromosome segregation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... HANOVER, Germany , March 20, 2017 At ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the ... Japan is this year,s CeBIT partner country. At the largest ... important biometrics in use: fingerprint, face and iris recognition as well as ... ...
(Date:3/9/2017)... MELBOURNE , Australia , March ... clinical study data at the prestigious World Lung Imaging ... Dr. Andreas Fouras , was invited to deliver ... and pulmonary medicine. This globally recognised event brings together ... and share the latest developments in lung imaging. ...
(Date:3/6/2017)... , March 6, 2017 ... sales technology, today announced Predictive Sales Coach TM ... infusing actionable sales intelligence into Salesforce. This unique ... enable their sales organizations with deep knowledge of ... allow for intelligent engagement. Predictive Sales Coach extends ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... 2017 Sinovac Biotech Ltd. ("Sinovac" or the "Company") (NASDAQ: ... , today announced that its board of directors has amended ... plan from March 27, 2017 to March 27, 2018. The amendment was ... Sinovac Biotech Ltd. ... Sinovac Biotech Ltd. is a China ...
(Date:3/23/2017)... ... March 23, 2017 , ... AxioMed president, ... viscous and elastic characteristics when deformed, which is identical to how the human ... absorb compressive forces and return to its natural state along a hysteresis curve, ...
(Date:3/23/2017)... March 23, 2017  SeraCare Life Sciences, ... in vitro diagnostics manufacturers and clinical laboratories, ... first multiplexed Inherited Cancer reference material ... by next-generation sequencing (NGS). The Seraseqâ„¢ Inherited Cancer ... input from industry experts to validate the ...
(Date:3/23/2017)... March 23, 2017 Kineta, Inc., a ... novel therapies in immuno-oncology, today announced the discovery ... molecule compounds that activate interferon response factor 3 ... demonstrate immune-mediated tumor regression in a murine colon ... who demonstrated complete tumor regression to initial drug ...
Breaking Biology Technology:
Cached News: