HOME >> BIOLOGY >> NEWS
An irregular heartbeat makes exercise deadly

The results of a study in mice that was conducted by researchers from Vanderbilt University has provided a potential explanation for why the heartbeat of humans lacking the protein cardiac calsequestrin (CASQ2) is irregular, and potentially fatal, only during exercise and not at other times.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a life-threatening disease characterized by an irregular heartbeat during exercise. CPVT can be caused by mutations in the gene encoding CASQ2, which is a Ca2+-binding protein found in the Ca2+ storage facility of the muscle cells of the heart. Paradoxically, although CASQ2 is thought to have a crucial role in regulating contraction of the heart, individuals lacking both copies of CASQ2 and whose hearts contract relatively normally have been identified. In a study that appears online on August 24 in advance of publication in the September print issue of the Journal of Clinical Investigation, Bjrn Knollmann and colleagues generated Casq2-deficient mice to help explain this paradox. Similar to humans lacking CASQ2, Casq2-deficient mice showed normal heart contraction under basal conditions, but both exercise and exposure to catecholamines (which are chemicals such as epinephrine made by the body during exercise and stress) induced an irregular heartbeat. The authors found that the lack of Casq2 was compensated for in several ways, including a substantial increase in the volume of the Ca2+ storage facility in the muscle cells of the heart, such that under basal conditions the heartbeat was regular. However, when exposed to catecholamines, a lack of Casq2 caused Ca2+ to spontaneously leak from its storage facility and trigger an inappropriate heartbeat. This study identifies the mechanisms behind the irregular heartbeats caused by a lack of Casq2, and might explain why the hearts of humans lacking CASQ2 beat relatively normally, but can beat irregularly and put these individuals at risk of sudden death whe
'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
24-Aug-2006


Page: 1 2

Related biology news :

1. Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
2. New approach for genetic screening for syndrome linked to cardiac irregularities and sudden death
3. Global heartbeat control suggests therapy for beating heart failure
4. Researchers identify a heartbeat in Earths climate
5. Altering a protein makes mice less fearful
6. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
7. Book makes case for using evolution in everyday life
8. Dartmouth professor makes case for ethically universal stem cell lines
9. A nurse makes the decision on who will live
10. NASA-funded robotic sub makes final dive to reach bottom of Earths deepest sinkhole
11. Personality-gene makes songbirds curious

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/30/2018)... ... 30, 2018 , ... TC Slade, an evidence-based healer, today ... healing treated Vitamin D3 on the strength and health of bones. , ... in ALP, a bone-specific enzyme ,     Over 240% increase in collagen levels ...
(Date:7/28/2018)... ... July 28, 2018 , ... Inthirani Arul, an evidence-based healer, today ... to combat inflammation and autoimmune disorders. , Biomarkers for immune function, blood, as ... , Over 110% increase in overall immunity as seen by the rise ...
(Date:7/27/2018)... ... July 27, 2018 , ... ... Group (BRAG®) and representatives of the Biotechnology Innovation Organization (BIO) met with ... white paper, ‚ÄúProposal for a Toxic Substances Control Act (TSCA) Inventory Representation ...
Breaking Biology News(10 mins):
(Date:8/9/2018)... ... August 09, 2018 , ... Simpson ... construction (AEC) experts with building owners and managers for a full-day discussion on ... Construct symposium comes to Boston for the first time on Thursday, 13 September ...
(Date:8/7/2018)... ... ... PetPace , the makers of a smart health-monitoring collar for pets, ... of a groundbreaking study to identify and eventually predict problems and complications affecting pregnant ... sponsored by PetPace and conducted by Dr. Smadar Tal, DVM, DACT, DECAR, a veterinarian ...
(Date:7/31/2018)... ... July 31, 2018 , ... Leading ... covers methods for extracting and using adipose tissue-derived stem cells to treat or ... While this patent covers Canada specifically, VetStem has been issued similar patents ...
(Date:7/31/2018)... ... July 31, 2018 , ... ... announces the launch of their new website. The new website has been designed ... site. Mahoney partnered with Proceed Innovative to build a website created for the ...
Breaking Biology Technology:
Cached News: