HOME >> BIOLOGY >> NEWS
Analysis reveals extent of DNA repair army

Cells have the remarkable ability to keep track of their genetic contents and -- when things go wrong to step in and repair the damage before cancer or another life-threatening condition develops.

But precisely how cells monitor the integrity of their genomes, identify problems, and intervene to repair broken or miscoded DNA has been one of nature's closely held secrets. Now, however, a report in the journal Science describes a new database developed by a team of researchers from the Howard Hughes Medical Institute at Harvard Medical School that is providing the first detailed portrait of the army of more than 700 proteins that helps maintain DNAs integrity.

"The generation of this database is changing the way we think about the DNA damage response," explained HHMI investigator Stephen J. Elledge of Harvard, the senior author of the new study published on May 25, 2007, in Science. "Our work paints a broader landscape of this critical response that helps cells keep their genomes intact."

The DNA damage response is a routine event in the life of any cell. Stress caused by environmental factors such as exposure to ultraviolet light, ionizing radiation or other environmental phenomena can cause DNA to break apart or rearrange its nucleotide base pairs in unhealthy ways. If such mutations are left unchecked, they can accumulate over time and lead, ultimately, to cancer or diabetes.

Elledge likened the DNA damage response to a command and control center: "It sends out sensors and sends out an alarm to start activating different repair pathways."

Elledge explained that two critical enzymes, known in scientific shorthand as ATM and ATR, act like sensors to detect trouble and initiate the DNA damage response by engaging the cell's molecular repair apparatus. By looking to see how ATM and ATR reacted to damage in cells, Elledge's group found that a small molecular army -- more than 700 different proteins -- is called into physiological actio
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
24-May-2007


Page: 1 2 3

Related biology news :

1. DOE JGI upgrades its Microbial Genome Analysis System
2. Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps
3. DOE JGI upgrades IMG/M -- the Metagenomics Data Management & Analysis System
4. Analysis of breast-cancer gene role offers promising target
5. The Center of Nutrigenomics of the TU Munich licences Genomatix Microarray Analysis Pipeline
6. Analysis highlights areas for research into genetic causes of alcoholism
7. German Microarray Excellence Center integrates Genomatix Chip Analysis Pipeline
8. Genomatix Microarray Analysis Pipeline achieves Affymetrix GeneChip compatible status
9. Analysis of Katrinas health, environmental effects to be aided by website with layers of data
10. Bioforensics Analysis Research and Development Center created at Los Alamos
11. Analysis of flower genes reveals the fate of an ancient gene duplication

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Analysis reveals extent DNA repair army

(Date:10/29/2014)... Online registration is open for the ... Scientific Meeting. SIR 2015 is the one ... trainees and related health care professionals can ... image-guided science and technologies being presented, discussed ... community in minimally invasive, image-guided medicine, SIR ...
(Date:10/29/2014)... sunlight to make their food, but they also need protection ... discovered a group of molecules in plants that shields them ... Journal of the American Chemical Society , one team reports ... , Timothy Zwier and colleagues at Purdue University note that ... cause serious damage to plant DNA and, as a result, ...
(Date:10/29/2014)... the rage. Thousands of scientists worldwide are conducting research ... dioxide nanoparticles from sun creams can get through the ... electronic products are as hazardous for the lungs as ... can get into the blood via the intestinal flora, ... flowing – and the number of scientific projects is ...
Breaking Biology News(10 mins):SIR 2015: Interventional radiology shapes tomorrow's medicine 2Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3
(Date:10/31/2014)... The report "Offshore Support Vessel Market ... Supply Vessels, Multi-Purpose Service Vessel, Crew Boats, Standby & ... Trends & Forecast to 2018", defines and segments the ... the global revenue. , Offshore support vessel market is ... to $ 91,228.8 Million by 2018, with a CAGR ...
(Date:10/31/2014)... IL (PRWEB) October 30, 2014 ... Insight Product Developmentā€™s decades-long heritage in successful medical ... world context for what it takes to successfully ... space. As part of a two-hour on-site class, ... Kellogg school of business, McCormick School of Engineering, ...
(Date:10/31/2014)... 31, 2014 This is a ... China Biocides industry. The report provides basic biocides ... chain structure as well as industry overview. This ... domestic market as well as Global industry analysis ... report on the Chinese biocides industry ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Stronger ... healthcare, construction, finance and consumer electronics will help ... reason, industry research firm IBISWorld has added a ... its growing industry report collection. , The Biometrics ... for biometric technologies such as fingerprint, iris, retina ...
Breaking Biology Technology:Offshore Support Vessel Market Projected to Reach $91,228.8 Million by 2018 - Report by MarketsandMarkets 2Offshore Support Vessel Market Projected to Reach $91,228.8 Million by 2018 - Report by MarketsandMarkets 3Offshore Support Vessel Market Projected to Reach $91,228.8 Million by 2018 - Report by MarketsandMarkets 4Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 2Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 3Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 3Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3
Cached News: