Scientists have confirmed the existence of protein in soft tissue recovered from the fossil bones of a 68 million-year-old Tyrannosaurus rex (T. rex) and a half-million-year-old mastodon.

Their results may change the way people think about fossil preservation and present a new method for studying diseases in which identification of proteins is important, such as cancer.

When an animal dies, protein immediately begins to degrade and, in the case of fossils, is slowly replaced by mineral. This substitution process was thought to be complete by 1 million years. Researchers at North Carolina State University (NCSU) and Harvard Medical School now know otherwise.

The researchers' findings appear as companion papers in this week's issue of the journal Science.

"Not only was protein detectably present in these fossils, the preserved material was in good enough condition that it could be identified," said Paul Filmer, program director in the National Science Foundation (NSF) Division of Earth Sciences, which funded the research. "We now know much more about what conditions proteins can survive in. It turns out that some proteins can survive for very long time periods, far longer than anyone predicted."

Mary Schweitzer of NCSU and the North Carolina Museum of Natural Sciences discovered soft tissue in the leg bone of a T. rex and other fossils recovered from the Hell Creek sediment formation in Montana.

After her chemical and molecular analyses of the tissue indicated that original protein fragments might be preserved, she turned to colleagues John Asara and Lewis Cantley of Harvard Medical School, to see if they could confirm her suspicions by finding the amino acid used to make collagen, a fibrous protein found in bone.

Bone is a composite material, consisting of both protein and mineral. In modern bones, when minerals are removed, a collagen matrix--fibrous, resilient material that gives the bones str
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Contact: Cheryl Dybas
cdybas@nsf.gov
703-292-7734
National Science Foundation
12-Apr-2007