HOME >> BIOLOGY >> NEWS
Ancient retrovirus sheds light on modern pandemic

SEATTLE -- Human resistance to a retrovirus that infected chimpanzees and other nonhuman primates 4 million years ago ironically may be at least partially responsible for the susceptibility of humans to HIV infection today.

These findings, reported by a team of researchers at Fred Hutchinson Cancer Research Center in the June 22 issue of Science, provide a better understanding of this modern pandemic infection through the study of an ancient virus called Pan troglodytes endogenous retrovirus, or PtERV1.

"This ancient virus is a battle that humans have already won. Humans are not susceptible to it and have probably been resistant throughout millennia," said senior author Michael Emerman, Ph.D., a member of the Human Biology and Basic Sciences divisions at the Hutchinson Center. "However, we found that during primate evolution, this innate immunity to one virus may have made us more vulnerable to HIV."

Evidence of human immunity to this ancient retrovirus first emerged with the sequencing of the chimpanzee genome. "When the chimp genome was sequenced, a team of scientists at the University of Washington led by Evan Eichler found the largest difference overall between the chimp and human genomes was the presence or absence of PtERV1," Emerman said. "Chimps have 130 copies of PtERV1 and humans have none."

It is believed that retroviruses have been entering the genome for many millions of years, and so humans share many retroviral DNA fragments with their primate cousins. Such vestiges of primitive infection, rendered inactive by eons of genetic mutation, make up about 8 percent of the human genome.

Innate protection against PtERV1 in humans could be credited, the researchers believe, to the presence of an ancient, rapidly evolving antiviral defense gene called TRIM5a, which produces a protein that binds to and destroys the virus before it can replicate within the body.

"We know that PtERV1 infected chimps, gorillas and old-world monkey
'"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
21-Jun-2007


Page: 1 2 3

Related biology news :

1. Ancient Etruscans were immigrants from Anatolia, or what is now Turkey
2. Ancient DNA traces the woolly mammoths disappearance
3. Ancient amphibians evolved a bite before migrating to dry land
4. Ancient T. rex and mastodon protein fragments discovered, sequenced
5. Ancient coral reef tells the history of Kenyas soil erosion
6. Ancient genes used to produce salt-tolerant wheat
7. Ancient climate change may portend toasty future
8. Ancient ape ruled out of mans ancestral line
9. Ancient predator had strongest bite of any fish, rivaling bite of large alligators and T. rex
10. Ancient birds flew on all-fours
11. Ancient raptors likely feasted on early man, study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around ... the use of mass spectrometry in this field has gained a lot of momentum ... choose which approach to use (LBA or MS)?” In many cases, either technology ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... In its ... feature interview with Dr. James L. Sherley, M.D., Ph.D., founder and director of ... the company announced on June 16 that starting July 5 it would ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... for Data Decisions,” for pharmaceutical and biotech executives, laboratory managers, scientists, researchers ... scientific instruments and laboratory equipment from dozens of manufacturers into their lab. ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... , ... True Terpenes , the leading platform for terpene innovation, research ... research the medical potential of terpenes and the potential entourage effect , where ... is focused on expanding the recently launched line of effects-based terpenes - Terpology ...
(Date:8/7/2020)... ... 06, 2020 , ... VGXI, a highly regarded CDMO supporting ... purchase of greenfield for a new, expanded manufacturing facility. The site is located ... the initial acquisition, with an option to purchase an additional 21 acres for ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and ... can drive one or two switches in a push-pull configuration; yielding fast fall ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
Breaking Biology Technology:
Cached News: