HOME >> BIOLOGY >> NEWS
Animals resistant to drunken behavior offer clues to alcoholism's roots

Animals with a remarkable ability to hold their liquor may point the way toward the genetic underpinnings of alcohol addiction, two separate research teams reported in the October 6, 2006 issue of the journal Cell. Earlier studies have shown that people with a greater tolerance for alcohol have a greater risk of becoming alcoholics, according to the researchers.

In one study, researchers at the Fondazione Istituto FIRC di Oncologia Molecolare in Italy found that mice lacking a gene that influences the cellular "skeleton" become less susceptible to the intoxicating effects of alcohol. The animals consequently drink more ethanol than the average mouse, they reported. They further showed that the mutant animals' neurons became less sensitive to "remodeling" of the cytoskeleton that otherwise follows ethanol exposure.

In the second paper, a team of researchers led by Adrian Rothenfluh and Ulrike Heberlein at the University of California, San Francisco characterized flies that carried a mutation rendering them invulnerable to drunken behavior. They discovered that the ethanol-resistant flies failed to produce a regulatory protein underlying the sedative effects of alcohol. The lacking protein is one of three encoded by a single gene and is also suspected to influence the cytoskeleton of neurons, though indirectly.

"Most researchers in the alcohol field have focused on cell surface receptors--with little attention to the role of the cytoskeleton," said Ulrike Heberlein at UCSF, who is an author on both papers. "Now, these two papers have, through very different means, come to highlight a possible role of the actin cytoskeleton in behavioral responses to ethanol."

Cytoskeletal defects may have the ability to simultaneously change the dynamics of multiple receptors, she said. "These animals are tremendously resistant to alcohol. There seems to be something very central about the observed changes to their behavior."

Cytos
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
5-Oct-2006


Page: 1 2 3 4

Related biology news :

1. Koshland Science Museum Program: Animals and their habitat
2. National Academies Advisory: April 10 Meeting on Distress in Lab Animals
3. Animals can change genes quickly to keep up with viral ingenuity
4. Animals warn of human health hazards in new Canary Database
5. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
6. New way to target and kill antibiotic-resistant bacteria found
7. First all-African produced genetically engineered maize is resistant to maize streak virus
8. Malaria-resistant mosquitoes battle disease with molecular warhead
9. Wellcome Trust and GlaxoSmithKline announce partnership to target drug-resistant hospital infections
10. Arming the fight against resistant bacteria
11. Researchers uncover protection mechanism of radiation-resistant bacterium

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. today ... by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the ... and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet surge ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study ... the Invictus Medical Neoasis™ active noise control device to attenuate typical noises in ... Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and other bedside ...
(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced the ... share insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content ... will be live on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... TORONTO (PRWEB) , ... July 22, 2020 , ... Join ... and John Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar ... is the regulating body in China for drugs and medical devices. Specifically, for medical ...
(Date:7/10/2020)... LORTON, Va. (PRWEB) , ... July 08, 2020 ... ... laboratory testing services and products, announces a significant expansion of laboratory operations through ... robust collection for agencies implementing testing programs. , Bode-CARES provides ...
(Date:7/7/2020)... (PRWEB) , ... July 06, 2020 , ... ... Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, ... 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples of ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 ... or drug treatment. In an effort to better understand the cellular responses to ... largest imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced ...
Breaking Biology Technology:
Cached News: