HOME >> BIOLOGY >> NEWS
Another gene rearrangement involved in prostate cancer identified

Researchers at the University of Michigan Medical School have identified a third gene involved in prostate cancer, expanding their groundbreaking announcement, published last October in Science, that the majority of prostate cancers carry a malignancy-inducing fusion of genes never before seen in solid tumors. The new findings appear in the April 1 issue of Cancer Research. Since prostate cancer is a cancer of the epithelial cells lining organs, lead researcher Arul Chinnaiyan and his colleagues believe it likely that other gene re-arrangements may be responsible for other cancers of epithelial tissue, including breast, colon and lung.

Scott Tomlins, a MD/PhD graduate student in Dr. Chinnaiyan's laboratory and the lead author of the Science paper, presented the study Tuesday, April 4, at Experimental Biology 2006 in San Francisco. The presentation was part of the scientific program of the American Society for Investigative Pathology (ASIP) held at Experimental Biology, and Mr. Tomlins is the winner of the 2006 ASIP Experimental Pathologist-in-Training Award.

The ETV4 gene is a member of the same family as the two other genes, ETV1 and ERG, reported earlier. All three are ETS genes, a group of approximately 30 genes that encode related transcription factors. Like other family members, ETV4 has a role in normal cell division but is unusually active, or overly expressive, only when it becomes fused with other genes on different chromosomes. Using the same technology as the earlier study, the scientists were able to demonstrate that the ETV4 gene had become fused with another prostate cancer gene on another chromosome.

But the new ETV4 gene has two important differences from the ETV1 and ERG genes. First, while not overexpressed in individuals without prostate cancer, ETV4 is overexpressed in a much smaller fraction of patients with prostate cancer than the malignancy-causing genes described earlier. Second, the over-expressed ETV4 gen
'"/>

Contact: Sylvia Wrobel
415-905-1015
Federation of American Societies for Experimental Biology
3-Apr-2006


Page: 1 2

Related biology news :

1. Another sexual attraction is possible ...
2. Another world-first for LCTs Xeno facilities
3. Another boost for stem cell research
4. Another grape excuse to hit the bottle
5. Another great boost to medical research
6. Another world-record achievement for National High Magnetic Field Laboratory
7. Acid rain and forest mass: Another perspective
8. Chromosome rearrangements not as random as believed
9. U-M researchers identify gene involved in breast cancer
10. Identified main genetic variants involved in response to HIV
11. Oregon researchers involved in new Clovis-age impact theory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2019)... ... January 03, 2019 , ... ... cell culture models into their drug discovery research workflows with biology ranging from ... in vivo relevancy of in vitro studies, they create several challenges that need ...
(Date:12/22/2018)... BOSTON (PRWEB) , ... December 21, 2018 , ... ... office sponsored and hosted the Boston Healthcare Drinks event featuring Helen Chen, ... Opportunities Arising from China.” , The discussion was moderated by patent attorney ...
(Date:12/18/2018)... ... December 18, 2018 , ... The nation’s leader ... client marketing. The technology has been effective at reducing patient acquisition costs by ... working with clients nationwide on patient acquisition marketing programs. Traditional marketing for stem ...
Breaking Biology News(10 mins):
(Date:12/19/2018)... ... 2018 , ... RURO, Inc., a leading provider of information ... The new release enhances the latest version of Limfinity®, RURO’s software framework, and ... , Validation protocols, and their execution, are critical for software systems scrutinized by ...
(Date:12/18/2018)... (PRWEB) , ... December 18, 2018 , ... ... business process optimization firm for the life sciences industry, unveiled a completely redesigned ... while creating a more user-friendly browsing experience for their valued clients and business ...
(Date:12/14/2018)... EDMONTON, Alberta (PRWEB) , ... December 14, 2018 ... ... the Eye Machine Canada Inc., have been given the green light to immediately ... Age-Related Macular Degeneration (AMD). , The medical devices bureau of Health Canada has ...
(Date:12/13/2018)... , ... December 12, 2018 , ... ... life science software solutions, announces the Limfinity® ML (Machine Learning) addition for its ... machine learning models within Limfinity® solutions. In the module, trained models make predictions ...
Breaking Biology Technology:
Cached News: