HOME >> BIOLOGY >> NEWS
Anthrax bacterium's deadly secrets probed

New insights into why the bug that causes anthrax behaves in the unusual way that it does have come to light thanks to a development under the UK e-Science Programme. Researchers at the North East Regional e-Science Centre have found that the proteins the anthrax bacterium secretes equip it to grow only in an animal host and not in the soil.

This finding sheds light on why Bacillus anthracis does not grow in soil, even though in many ways it resembles a soil-growing bacterium. It has the ability to lie dormant in soil for, in some cases, hundreds of years and then to cause a rapid, often fatal, illness when ingested by a suitable animal host. Bioterrorists have exploited this ability to deadly effect.

Dr. Anil Wipat, Professor Colin Harwood, Tracy Craddock and colleagues at the North East Regional e-Science Centre in Newcastle revealed the new insights after developing a method for deducing and characterising the proteins a bacterium secretes simply from a knowledge of its genome sequence.

Secreted proteins equip a bacterium to survive in its environment and so reveal much about its lifestyle. A soil-living bacterium, for example, secretes proteins that enable it to take up nutrients from the soil. A disease-causing bacterium may secrete proteins that subvert the hosts immune system, enabling the bacterium to infect cells or survive in the bloodstream. Knowledge of a pathogenic bacteriums secreted proteins and how they function can therefore help with the search for treatments.

As genes carry the code for proteins, researchers are able to use knowledge of a bacteriums genes to deduce all the proteins it produces. Difficulty arises when trying to pick out only the proteins that are secreted. Methods exist to do this, but are very time-consuming, given that many bacteria secrete 4000 or more proteins. Now, however, the Newcastle researchers have developed an automatic method which makes the identification, analysis an
'"/>

Contact: Dr. Anil Wipat
anil.wipat@newcastle.ac.uk
01-912-228-213
Research Councils UK
6-Aug-2007


Page: 1 2 3

Related biology news :

1. Anthrax paralyzes immune cells with lethal toxin, UF research shows
2. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
3. Anthrax spores may survive water treatment
4. Anthrax stops body from fighting back, study shows
5. Anthrax test, developed by army and CDC, receives FDA approval
6. Anthrax inhibitors identified by Burnham team
7. Research aims to identify markers for menopausal women at risk for deadly blood clot
8. BRCA2 carriers at increased risk for deadly form of prostate cancer
9. Cornell lab confirms deadly fish virus spreading to new species
10. Gene that governs toxin production in deadly mold found
11. Study pries into ovarian cancers deadly secrets

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... , ... October 12, 2017 , ... ... today announced the three Winners and six Finalists of the 2017 Blavatnik Regional ... by the Blavatnik Family Foundation and administered by the New York Academy of ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... with the addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s ... hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical ...
(Date:10/11/2017)... ... 2017 , ... At its national board meeting in North ... the co-founder, CEO and chief research scientist of Minnesota-based Advanced Space Technology and ... ARCS Alumni Hall of Fame . ASTER Labs is a technology development ...
(Date:10/11/2017)... CA, USA (PRWEB) , ... October 11, 2017 , ... ... to take place on 7th and 8th June 2018 in San Francisco, CA. The ... influencers as well as several distinguished CEOs, board directors and government officials from around ...
Breaking Biology Technology:
Cached News: