Anthrax paralyzes immune cells with lethal toxin, UF rese...( uthwick said adding that victims of in...)

Anthrax paralyzes immune cells with lethal toxin, UF research shows

uthwick said, adding that victims of inhalational anthrax often suffer hemorrhages in their lungs and lymph nodes. "No one understands why, and it could very well be due to paralysis of platelets." During and Southwick are currently looking for additional proteins targeted by anthrax. They hope to develop a diagnostic blood test that detects the bacterium by checking for telltale changes in protein expression.

Southwick's team used an unusual approach to tease out the anthrax toxin's effects on cell migration: They allowed the immune cells to be hijacked by another bacterium, Listeria monocytogenes. Listeria is often used as a tool to study actin because it commandeers human cells and induces them to form the filaments, which the bacteria use to navigate around the body.

"We used one bacterium to weed out another. I'm not aware of anyone ever doing that," Southwick said. "In an individual cell, you can't figure out where the actin is assembling and what's controlling it. But Listeria seems to use the same pathways that a cell uses to crawl. So anything that blocks Listeria we predict would also block neutrophils from crawling. And that's what we found."

Contact: Ann Griswold
anngriswold@gmail.com
352-273-5810
University of Florida
5-May-2007

Page: 1 2 3
Related biology news :

1. Anthrax bacteriums deadly secrets probed
2. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
3. Anthrax spores may survive water treatment
4. Anthrax stops body from fighting back, study shows
5. Anthrax test, developed by army and CDC, receives FDA approval
6. Anthrax inhibitors identified by Burnham team
7. Bursts of waves drive immune system soldiers toward invaders
8. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
9. A stepwise retreat: How immune cells catch pathogens
10. Link between immune system and mammary gland could shed new light on breast cancer
11. Researchers discover method for identifying how cancer evades the immune system

Post Your Comments:

(Date:11/23/2009)...ated strain of the deadly superbug MRSAan infectio...oticsposes a far greater health threat than previo...ccording to a study in the December issue of Emer...easily picked up in fitness centers, schools, and ...burden of MRSA within hospitals, the report found....

(Date:11/23/2009)...tion Society says that western lowland gorillas li... of the "mother lode" of more than 125,000 gorilla...reatened by growing humans activity in the region....forests adjacent to the southwest border of Lac Tl...that high densities of the great apes still exist ...

(Date:11/23/2009)...s "incontrovertible evidence" that the volcanic su...t 73,000 years ago deforested much of central Indi...s report. , The volcano ejected an estimated 800...ing a crater (now the world,s largest volcanic lak...ide. Ash from the event has been found in India, t...

Breaking Biology News(10 mins):New study finds MRSA on the rise in hospital outpatients 2 A year after discovery, Congo's 'mother lode' of gorillas remains vulnerable 2 Supervolcano eruption -- in Sumatra -- deforested India 73,000 years ago 2 MassMutual Survey 3A Female Cancer Survivors Better Prepared Financially Than Other Women For Lifes Unexpected Events 47976 1 MassMutual Survey 3A Female Cancer Survivors Better Prepared Financially Than Other Women For Lifes Unexpected Events 47976 2 MassMutual Survey 3A Female Cancer Survivors Better Prepared Financially Than Other Women For Lifes Unexpected Events 47976 3 MassMutual Survey 3A Female Cancer Survivors Better Prepared Financially Than Other Women For Lifes Unexpected Events 47976 4 MassMutual Survey 3A Female Cancer Survivors Better Prepared Financially Than Other Women For Lifes Unexpected Events 47976 5 Crowded emergency departments pose greater risks for patients with heart attacks 47973 1 Crowded emergency departments pose greater risks for patients with heart attacks 47973 2 Crowded emergency departments pose greater risks for patients with heart attacks 47973 3 Canadian based UN coral reef expert honored at world meeting in Australia 8727 1 Canadian based UN coral reef expert honored at world meeting in Australia 8727 2

[2] New study finds MRSA on the rise in hospital outpatients [0] A year after discovery, Congo's 'mother lode' of gorillas remains vulnerable [0] Supervolcano eruption -- in Sumatra -- deforested India 73,000 years ago

(Date:11/24/2009)...CITY,Calif.,Nov.24/PRNewswire-FirstCall/--GenomicH...ott,GenomicHealth,sExecutiveChairman,willpresentat...YorkCityonTuesday,December1,2009at10:00a.m.ET. ,...thepresentation,visittheInvestorRelationssectionof...alth.com .Pleaseconnecttothewebsiteatleast15minute...

(Date:11/24/2009)... Program Connects Customers with Partner...ed with DNA Genotek Products , ... Genotek , a leading provider of products for biol...ation, today announced its new global partner prog...or DNA Genotek,s partner community and is designed...

(Date:11/24/2009)...,Nov.24/PRNewswire-FirstCall/--CellTherapeutics,In...he21stAnnualPiperJaffrayHealthCareConference.Theco...aceHotel. ,, CTIwillpresentonTuesday,December1a...owebcastofCTI,spresentationwillbeavailableat www.c...playafterwards. , ,PiperJaffrayHealthCareConferen...

(Date:11/23/2009)...l. You can think of it as origami very high-tech...nois have developed a technique for fabricating th...ures from thin films by coupling photolithography ...eractions. , The films, only a few microns thick,... with thicker pieces of the same material. , "Thi...

Breaking Biology Technology:Genomic Health to Present at Piper Jaffray Health Care Conference 2 DNA Genotek Launches Global Partner Program 2 DNA Genotek Launches Global Partner Program 3 Water droplets direct self-assembly process in thin-film materials 2

[0] Genomic Health to Present at Piper Jaffray Health Care Conference [0] DNA Genotek Launches Global Partner Program [0] Cell Therapeutics, Inc. (CTI) to Present at 21st Annual Piper Jaffray Health Care Conference [0] Water droplets direct self-assembly process in thin-film materials

Other News:

...hale's future looks grim if the current mortality ...ity assistant professor of oceanography Douglas No... the nation.... ...They have co-authored a paper...at appears in the July 22 edition of the journal S...

...identified the first genetic mutations that cause ...and rupture.......Published online by Circulation:...ndings of a team led by University of Texas Medica...the molecular causes of thoracic aortic aneurysms ...

...evolution of protein design by a University of Hou...esentations at the 2005 Nano Summit Research Confe... professor of biology and biochemistry at UH, will...otein Design in Bionanotechnology." ......Sponsor...

...chungsgemeinschaft (DFG, German Research Foundatio...cal Compounds in the Work Area has presented the 2...eitsplatzkonzentrationen MAK) and Biological Tole...e BAT) list and submitted it to the German Federa...

FSU scientist warns North Atlantic right whale facing extinction 2 Gene's mutations found to cause life-threatening aortic disease 2 Gene's mutations found to cause life-threatening aortic disease 3 Disease diagnosis, bioengineering covered at state nano summit 2 DFG presents the 2005 MAK and BAT value lists 2 DFG presents the 2005 MAK and BAT value lists 3 DFG presents the 2005 MAK and BAT value lists 4 DFG presents the 2005 MAK and BAT value lists 5

FSU scientist warns North Atlantic right whale facing extinction Gene's mutations found to cause life-threatening aortic disease Disease diagnosis, bioengineering covered at state nano summit DFG presents the 2005 MAK and BAT value lists

...d and other rain in September have ended .drought ...Streamflow and .ground-water levels across the sta... had stretched from the mid-Atlantic states throug...The U.S. Geological Survey (USGS) .monitors water ...

...me, researchers have proven that smoke from forest...ished in the October 15 issue.of Geophysical Resea... data.taken from NASA's Tropical Rainfall Measuri...t the "warm rain" processes that often create rain...

... at the University of Illinois have isolated,.sequ...arine mollusk Aplysia.californica. The gene's str...hat of human insulin -- possesses an additional pe...ost all animals, from corals to humans, make and u...

... is getting worse on your commute, you're not alon...ousands of passengers from the.U.S. to Europe each...et super.highway in the world: the Atlantic corrid...triment to the atmosphere at 35,000 feet the way t...

Effect of Hurricane Floyd on current water resources in Maine 2 Spacecraft provides first direct evidence: Smoke in the atmosphere inhibits rainfall 2 Researchers characterize mollusk insulin gene, find unique peptide 2 Scientists look for signs of pollution in the superhighway in the sky 2

Effect of Hurricane Floyd on current water resources in Maine Spacecraft provides first direct evidence: Smoke in the atmosphere inhibits rainfall Researchers characterize mollusk insulin gene, find unique peptide Scientists look for signs of pollution in the superhighway in the sky