HOME >> BIOLOGY >> NEWS
Anthrax stops body from fighting back, study shows

GAINESVILLE, Fla. - University of Florida researchers have uncovered how the inhaled form of anthrax disarms bacteria-fighting white blood cells before they can fend off the disease, which kills most victims within days.

The lethal toxin in anthrax paralyzes neutrophils, the white blood cells that act as the body's first defense against infection, by impairing how they build tiny filaments that allow them to crawl throughout the body and eat invading bacteria.

Just two hours of exposure to the lethal toxin blocks the neutrophils' ability to produce these filaments by nearly 60 percent, paralyzing them and allowing the anthrax to move freely in the body, according to research released last week in The Journal of Infectious Diseases.

The need to find new ways to treat victims of bioterrorism has increased since the Sept. 11, 2001, terrorist attacks and the anthrax attacks that killed five people exposed to inhalation anthrax through the mail. The UF findings could lead to treatments that block anthrax from paralyzing the much-needed neutrophils, said Dr. Frederick Southwick, division chief of infectious diseases at the UF College of Medicine and the lead author of the paper.

"If your neutrophils work normally, you might be able to shut down this infection," said Southwick, who worked on the study with a team of UF researchers and investigators from the Centers for Disease Control and Prevention and Emory University. "The overall goal is to understand how anthrax toxins paralyze the immune system."

Researchers first noticed anthrax's effect on these white blood cells while reviewing the cases in the 2001 anthrax attacks.

The victims did not have elevated white blood cell counts, typical for most infections, and a large number of the inhaled anthrax bacteria had spread from the lungs into the bloodstream, which is unusual, Southwick said.

This led researchers to believe anthrax may be impairing the cells' abil
'"/>

Contact: April Frawley Birdwell
Afrawley@vpha.health.ufl.edu
352-273-5817
University of Florida
6-Sep-2005


Page: 1 2 3

Related biology news :

1. Anthrax bacteriums deadly secrets probed
2. Anthrax paralyzes immune cells with lethal toxin, UF research shows
3. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
4. Anthrax spores may survive water treatment
5. Anthrax test, developed by army and CDC, receives FDA approval
6. Anthrax inhibitors identified by Burnham team
7. Penn researchers discover how key protein stops inflammation
8. Chinese medicinal compound stops formation of cysts in polycystic kidney disease in lab
9. MIT material stops bleeding in seconds
10. One bacteria stops another on contact
11. Inexpensive treatment stops multi-drug resistant TB in its tracks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: