HOME >> BIOLOGY >> NEWS
Anti-wrinkle compound causes pathological reaction in skin cells

Quebec City, April 11, 2007 -- Researchers from Universit Lavals Faculty of Medicine have discovered that a compound commonly used in many antiwrinkle products causes a pathological reaction in skin cells. Guillaume Morissette, Lucie Germain, and Franois Marceau present their conclusions about the mode of action of this substancecalled DMAEin the latest edition of the British Journal of Dermatology.

DMAE (2-dimethylaminoethanol) is used in many antiwrinkle products dubbed "instant anti-aging face-lifts." This compound, as well as other chemically similar ones, are also found in cosmetics, creams, lipsticks, shampoos, soaps, and baby lotions, although the way they work is not yet understood.

In vitro tests conducted by Dr. Marceaus team revealed that the application of DMAE induces a quick and spectacular swelling of skin cell vacuoles called fibroblasts, which act as reservoirs and interface between the inside and the outside of the cell.

In the hours following the application of DMAE, the researchers observed an important slowing down of cell divisionsometimes coming to a complete stop, the inhibition of certain metabolic reactions, and the death of a significant percentage of fibroblasts. The mortality rate of fibroblasts, which varied according to DMAE concentration, was above 25% after 24 hours in the case of a concentration similar to the one resulting from normal use of an antiwrinkle cream. The thickening of the skin induced by the pathological swelling of the fibroblasts would explain the antiwrinkle effect of DMAE, according to the researchers.

"Even though DMAE is similar to medication, there is very little scientific documentation about its pharmacological and toxicological effects," explains Dr. Marceau, who stresses his goal is not to condemn the use of this compound. "Were not saying DMAE is dangerous to people exposed to it, but our results indicate its time to begin serious research to determine whether or n
'"/>

Contact: Jean-Franois Hupp
jean-francois.huppe@dap.ulaval.ca
418-656-7785
Universit Laval
11-Apr-2007


Page: 1 2

Related biology news :

1. A compound from olive-pomace oil gets 80 percent slowing down of HIV spread
2. New compound effectively treats fungal infections
3. Natural compound and exercise boost memory in mice
4. Lipoic acid explored as anti-aging compound
5. Pharmaceutical compounds found in nations fresh water
6. Chinese medicinal compound stops formation of cysts in polycystic kidney disease in lab
7. EPA selects Phylonix to screen compound library in zebrafish
8. Marine moss reveals clues to anticancer compound
9. New compound prevents alcoholic behavior, relapse in animals by blocking stress response
10. Light-activated compound silences nerves, may one day help epileptics
11. New compound isolated from Madagascan plant shows activity against malaria

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Anti wrinkle compound causes pathological reaction skin cells

(Date:8/28/2014)... called TX Invasives is now available from the Lady ... at Austin for identifying harmful non-native plant, insect and ... the United States cause about $137 billion in economic ... clog waterways, kill native plants and more. , "By ... reporting where invasive species occur, we,re more likely to ...
(Date:8/28/2014)... Entomological Society of America (ESA) is pleased to announce ... Member of the Society. Honorary Membership acknowledges those who ... significant involvement in the affairs of the Society that ... are selected by the ESA Governing Board and then ... be honored at the Awards Ceremony at Entomology 2014, ...
(Date:8/28/2014)... a handful of bacterial culprits that may drive inflammatory ... colitis, using patients, own intestinal immune responses as a ... the journal Cell . , Trillions of bacteria ... critical role in the development and progression of IBD. ... bacterial species affect a person,s susceptibility to IBD and ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2Fred Baxendale selected as Honorary Member of the Entomological Society of America 2Yale study identifies possible bacterial drivers of IBD 2
(Date:8/28/2014)... 2014 Best Sanitizers, Inc., a leader ... processing industry, is asking industry professionals to prepare for ... the E2 soap they’re currently using to the Best ... Hand hygiene is critical to fighting cross-contamination and ... Six key criteria are identified to evaluate the effectiveness ...
(Date:8/28/2014)... Best Sanitizers, Inc., the first company ... sanitizer, asks food processors and food handling professionals to ... they’re currently using to Best Sanitizers’ Alpet® E3 ... to fighting cross-contamination and the spread of pathogens in ... are key criteria that make a hand sanitizer most ...
(Date:8/28/2014)... “This kit has an improved extraction efficiency and provides users ... said Mark Tess, PhD, Mycotoxin Product Manager for Charm Sciences. ... USDA-GIPSA inspection agencies that have a need to detect aflatoxin ... a matter of minutes with nothing but our equipment and ... grain before accepting it, but they no longer have to ...
(Date:8/28/2014)... WEST LAFAYETTE, Ind. A new research ... "nanomechanical" properties of tiny structures undergoing stress ... insights to improve designs for microelectronics and ... spectroscopy, reveals information about how heating and ... their mechanical properties. Researchers have discussed the ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
Cached News: