The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Antibiotic identified as potential anti-cancer candidate

A molecular mechanism that was formerly thought to be important only in bacteria has now been shown to be a potential target for an anticancer therapy based on antibiotic use. David Scheinberg and colleagues, at the Sloan-Kettering Institute, have been investigating an enzyme in humans that is similar to one in bacteria called peptide deformylase (Pdf) and have found that an antibiotic called actinonin, which inhibits the human Pdf, also inhibits tumor growth. Pdf was thought to be important only to bacteria and the bacterially-related organelles of cells of higher organisms. Pdf is an enzyme that, during protein production, removes a modification called an N-formyl group from the first amino acid, a methionine, in the protein chain. While work began on the development of antibiotics against what was thought to be a bacterial-exclusive enzyme, genome-based data searches identified several classes of Pdf-like sequences in parasites, plants and mammals. Subsequent studies showed that the Pdfs were active both in culture and in the living organism, thus potentially derailing the usefulness of these antibiotics for specifically combating infectious agents. In previous studies, Scheinberg and colleagues had found that actinonin had an antiproliferative effect on human cancer cell lines and on tumor growth in a mouse model. They theorized this growth inhibitory activity might be related to actinonin's inhibition of human Pdf. The researchers now provide the evidence to support this theory. They show that human Pdf is active in the mitochondria and is essential for cellular growth and proliferation. They have designed and created a class of new actinonin-based Pdf inhibitors, and have demonstrated that they selectively inhibit growth in several human tumor cell lines. They further demonstrate that human tumor growth in mice can be suppressed by these Pdf inhibitors and suggest a mechanism of actinonin action. Taken together, these data have significant implicat
'"/>

Contact: Laurie Goodman
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
15-Oct-2004


Page: 1 2

Related biology news :

1. Antibiotic stress, genetic response and altered permeability of E. coli
2. Antibiotic treats lymphoma of the eye
3. Antibiotic inhibits cancer gene activity
4. Antibiotic resistance markers in GM plants not a risk to human health
5. Antibiotics may not be enough to stop recurrent gastric lymphoma caused by Helicobacter pylori
6. Antibiotics help combat dangerous tropical disease
7. Antibiotic resistant bacterium uses Sonar-like strategy to see enemies or prey
8. Antibiotic-resistant bacteria increased after clindamycin use for common vaginal infection
9. Link identified between Alzheimers disease and glaucoma
10. Gene identified for Crohns disease in children
11. New gene mutation identified in common type of dementia

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Antibiotic identified potential anti cancer candidate

(Date:11/24/2009)..., The presence of increased body fat, and there...he blood, hinders the loss and maintenance of body...versity of Navarra conducted by Estbaliz Goyeneche... The project, entitled "A nutrigenetic and nutrige...ght and inflammation," examines how the individual...
(Date:11/23/2009)...train of the deadly superbug MRSAan infection-caus...oses a far greater health threat than previously k...ng to a study in the December issue of Emerging I... picked up in fitness centers, schools, and other ... of MRSA within hospitals, the report found. , T...
(Date:11/23/2009)...ay matters to forest trees dealing with drought, a...m led by Professor Malcolm Campbell, University of... and colleagues in the department of cell and syst...lizing on their previous work to decode the genome...w poplar trees use their 45,000 genes to respond t...
Breaking Biology News(10 mins):It can be predicted the reaction obese patients will have to a diet 2New study finds MRSA on the rise in hospital outpatients 2Time of day matters to thirsty trees, U of T researcher discovers 2Anchor Bay Entertainment Joins Forces With Susan G Komen for the Cure 28R 29 in the Fight Against Breast Cancer 58593 1Anchor Bay Entertainment Joins Forces With Susan G Komen for the Cure 28R 29 in the Fight Against Breast Cancer 58593 2Anchor Bay Entertainment Joins Forces With Susan G Komen for the Cure 28R 29 in the Fight Against Breast Cancer 58593 3UAB professors book promises solution for teaching evolution without conflict 10199 1UAB professors book promises solution for teaching evolution without conflict 10199 2FDA Approves PRE PEN Penicillin Allergy Test 58590 1FDA Approves PRE PEN Penicillin Allergy Test 58590 2
(Date:11/24/2009)...pointhasbeenmetforpatientswithadvanced-stage,orrec...PRNewswire-FirstCall/-AEternaZentarisInc.(NASDAQ: ...calcompanyfocusedonendocrinetherapyandoncology,tod...hitstargetedcytotoxicpeptideconjugate,AEZS-108(for...metrialcancer.Inapersonalizedhealthcareapproach,th...
(Date:11/24/2009)...PRNewswire-FirstCall/--Shireplc(LSE:SHP,NASDAQ: S...today,announcedthatithassubmittedaMAAtotheEuropean...nzymereplacementtherapyindevelopment,forthetreatme...plicationforvelaglucerasealfathathasbeensubmitted,.... , Basedonaglobalsupplyshortageofthecurrentl...
(Date:11/24/2009)...,Nov.24/PRNewswire-FirstCall/--GenomicHealth,Inc.(...Health,sExecutiveChairman,willpresentatthe21stAnnu...uesday,December1,2009at10:00a.m.ET. ,, Toaccess...tion,visittheInvestorRelationssectionofGenomicHeal...leaseconnecttothewebsiteatleast15minutespriortothe...
(Date:11/24/2009)...Program Connects Customers with Partners Validated... Genotek Products , Ottaw...a leading provider of products for biological samp...y announced its new global partner program. The pr...tek,s partner community and is designed to help pa...
Breaking Biology Technology:AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 2AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 3AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 4Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 3Genomic Health to Present at Piper Jaffray Health Care Conference 2DNA Genotek Launches Global Partner Program 2DNA Genotek Launches Global Partner Program 3
Other News:
.... In much the same way that numerous films could b...age, a molecular process called alternative splici...ins. Now a new RNA map, created by a team of resea...ghes Medical Institute and announced in the journa...
...with direct ancestors of modern humans more than a...n once believed, clouding the notion that it was d...the African continent dried, says a new University...hows that Paranthropus robustus, once thought to b...
TALLAHASSEE, Fla. -- As the Northern Hemisphere braces for another flu season, researchers at Florida State University's National High Magnetic Field Laboratory are making strides toward better unders
... much detail one remembers of an event depends on ...d to "package" the memory.... The research may hel...s of an experience such as a car accident, and yet...perience.... In experiments using functional magne...
RNA map provides first comprehensive understanding of alternative splicing 2RNA map provides first comprehensive understanding of alternative splicing 3RNA map provides first comprehensive understanding of alternative splicing 4Varied diet of early hominid casts doubt on extinction theory, says Colorado U study 2Varied diet of early hominid casts doubt on extinction theory, says Colorado U study 3With BYU partner, FSU's Magnet Lab researchers deciphering flu virus 2Memories: It's all in the packaging, scientists say 2
...STANFORD, Calif. - People diagnosed with acute mye...y effective chemotherapy as a first line of attack...se resistant cancers, doctors move on to the next ...n development. This process is time-consuming and ...
...This release is also available in French...Nearly ...nd hear better than the sighted possibly to make ...t the Montreal Neurological Institute, McGill Univ...that the blind really do hear notes more precisely...
NEW BRUNSWICK/PISCATAWAY, N.J. — Rutgers veteran cancer prevention expert Harold Newmark knows how to simultaneously achieve a 20 percent reduction in colon cancer deaths and osteoporosis-related
CHILDREN with LEUKAEMIA Britain's leading charity dedicated exclusively to the conquest of childhood leukaemia is organising the first international scientific conference ever to be held into the in
New view of leukemia cells identifies best treatment options, Stanford researchers say 2New view of leukemia cells identifies best treatment options, Stanford researchers say 3The blind really do hear better 2Rutgers cancer prevention expert calls for FDA action to reduce colon cancer and osteoporosis 2First International Scientific Conference on Childhood Leukaemia 2