HOME >> BIOLOGY >> NEWS
Antibody linked to MS significantly higher in spinal fluid of blacks

St. Louis An antibody frequently used as a diagnostic marker for multiple sclerosis (MS) is present at greater levels in the cerebrospinal fluid of blacks with MS than Caucasians with the disease. The findings suggest that genetic differences among ethnic groups contribute to changes in the immune system, affecting susceptibility to MS. And they add another piece to a tantalizing but stubborn puzzle: Why do blacks get MS less often than other ethnic groups but suffer more serious symptoms when they develop the disease"

"These antibodies are indicators of inflammation, but we don't yet understand how inflammation is linked to prognosis," says first author John R. Rinker II, M.D., who did the work as a fellow at Washington University School of Medicine in St. Louis and is now assistant professor of neurology at the University of Alabama at Birmingham. "No one really understands yet why inflammation levels differ from one MS patient to the next."

The new study measured cerebrospinal fluid levels of IgG, an immune system antibody. Rinker and others have previously linked greater IgG to more aggressive MS in the general patient population. But that same link could not be reestablished in the new study, which assessed disease severity by comparing the time from MS diagnosis to when the patient first needed assistance walking. Black patients needed help walking sooner an average of nine years after diagnosis versus 17 years for Caucasians but on a case-by-case basis, scientists couldn't use greater IgG to predict an earlier need for assistance in walking.

"It may be that we haven't yet focused on the right disease characteristic or milestone in our search for factors that correlate with spinal inflammation," says Rinker. "I'm hoping to expand the search for correlations in follow-up studies."

The results are published in the July 3 issue of Neurology.

Epidemiologists estimate that 400,000 people in the United States have
'"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
2-Jul-2007


Page: 1 2 3

Related biology news :

1. Antibody-altering protein found in developing B cells
2. Antibody retards growth and induces death in liver cancer cells
3. Antibody-based therapies effective at controlling malaria
4. Antibody therapy prevents type 1 diabetes in mice
5. Antibody extends life of mice with breast cancer
6. Antibody to a naturally-occurring sugar chain in colon inhibits inflammatory bowel disease
7. Antibody that neutralizes most HIV strains described by scientists at The Scripps Research Institute
8. Protein chatter linked to cancer activation
9. Risk of common vaginal infection linked to preterm birth appears higher for blacks
10. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
11. Loss of cells antenna linked to cancers development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2019)... ... January 16, 2019 , ... January has been a record-breaking month so far ... has the company already hosted several of its signature cooking classes and team-building events, ... Pharmaceuticals, later this month. , Since 2008, Lajollacooks4u’s team-building events have been a ...
(Date:1/14/2019)... ... January 14, 2019 , ... ... detect precancer and cancer cells in blood, will present new findings at the ... the fight against colorectal cancer. The results from this study show CellMax Life’s ...
(Date:1/10/2019)... ... , ... When Dr. James L. Sherley, M.D., Ph.D., founder and director of ... to the new book Perinatal Stem Cells: Research and Therapy, he knew immediately what ... secret of stem cell medicine. For more than a half-century, stem cell medicine ...
Breaking Biology News(10 mins):
(Date:2/12/2019)... (PRWEB) , ... February 12, 2019 , ... ... in dermatology, has finalized a deal to extend their use of Medrio, the ... trials, through 2023. The CRO has been a regular Medrio customer for over ...
(Date:2/2/2019)... ... January 31, 2019 , ... Signature Matrix and ... perinatal tissue by applied stem cell research expert and Amazon best-selling author, Neil ... a flowable umbilical cord tissue allograft that originates from the same tissue used ...
(Date:1/30/2019)... ... 29, 2019 , ... Mr. Schieving has served as the ... Director of Sales and Marketing, Mr. Schieving was instrumental in positioning Lifecycle as ... supports. During this time, Mr. Schieving was responsible for establishing internal and external ...
(Date:1/30/2019)... N.J. (PRWEB) , ... January 30, 2019 , ... ... together experts from pharma, academia and governmental agencies to discuss best practices for ... DC from February 4-6. , At this year’s conference, Visikol will be ...
Breaking Biology Technology:
Cached News: