HOME >> BIOLOGY >> NEWS
Antibody linked to MS significantly higher in spinal fluid of blacks

St. Louis An antibody frequently used as a diagnostic marker for multiple sclerosis (MS) is present at greater levels in the cerebrospinal fluid of blacks with MS than Caucasians with the disease. The findings suggest that genetic differences among ethnic groups contribute to changes in the immune system, affecting susceptibility to MS. And they add another piece to a tantalizing but stubborn puzzle: Why do blacks get MS less often than other ethnic groups but suffer more serious symptoms when they develop the disease"

"These antibodies are indicators of inflammation, but we don't yet understand how inflammation is linked to prognosis," says first author John R. Rinker II, M.D., who did the work as a fellow at Washington University School of Medicine in St. Louis and is now assistant professor of neurology at the University of Alabama at Birmingham. "No one really understands yet why inflammation levels differ from one MS patient to the next."

The new study measured cerebrospinal fluid levels of IgG, an immune system antibody. Rinker and others have previously linked greater IgG to more aggressive MS in the general patient population. But that same link could not be reestablished in the new study, which assessed disease severity by comparing the time from MS diagnosis to when the patient first needed assistance walking. Black patients needed help walking sooner an average of nine years after diagnosis versus 17 years for Caucasians but on a case-by-case basis, scientists couldn't use greater IgG to predict an earlier need for assistance in walking.

"It may be that we haven't yet focused on the right disease characteristic or milestone in our search for factors that correlate with spinal inflammation," says Rinker. "I'm hoping to expand the search for correlations in follow-up studies."

The results are published in the July 3 issue of Neurology.

Epidemiologists estimate that 400,000 people in the United States have
'"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
2-Jul-2007


Page: 1 2 3

Related biology news :

1. Antibody-altering protein found in developing B cells
2. Antibody retards growth and induces death in liver cancer cells
3. Antibody-based therapies effective at controlling malaria
4. Antibody therapy prevents type 1 diabetes in mice
5. Antibody extends life of mice with breast cancer
6. Antibody to a naturally-occurring sugar chain in colon inhibits inflammatory bowel disease
7. Antibody that neutralizes most HIV strains described by scientists at The Scripps Research Institute
8. Protein chatter linked to cancer activation
9. Risk of common vaginal infection linked to preterm birth appears higher for blacks
10. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
11. Loss of cells antenna linked to cancers development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2018)... ... August 30, 2018 , ... USDM Life Sciences , the leading risk ... industries, has received the 2018 Services Partner of the Year, Awarded for Innovation from ... of Business Development and Platform Sales, Niall Wall and received by USDM Life Sciences ...
(Date:8/26/2018)... ... August 23, 2018 , ... Clinical laboratories have increasingly ... over more commonly used analytical techniques. However, implementation can be daunting due to ... validation of methods that must be undertaken by the laboratory if they are ...
(Date:8/23/2018)... , ... August 22, 2018 , ... ... of LimitLIS® 4.0, the latest version of its rapidly growing cloud-based laboratory information ... Toxicology Edition, as well as the company’s triple digit growth throughout 2018, the ...
Breaking Biology News(10 mins):
(Date:9/7/2018)... ... September 06, 2018 , ... Flagship Biosciences’ MuscleMap ... validated to be as effective as manual pathology. The study, “Validation of a ... Biopsies,” was published in the Archives of Pathology & Laboratory Medicine on August ...
(Date:8/31/2018)... ... August 29, 2018 , ... A ... University of Southampton and the Institute of Industrial Science, the University of Tokyo, ... dramatically accelerate the exploration and study of hard to reach deep sea ecosystems, ...
(Date:8/29/2018)... ... August 28, 2018 , ... Cognition Corporation ®, a ... of talks for NAVIGATE2018 . , Ryan Ward, Director of Engineering at ... user conference. An experienced engineer and manager with Zimmer Biomet for almost 15 years, ...
(Date:8/29/2018)... (PRWEB) , ... August 28, 2018 , ... LabRoots ... from around the world, is proud to announce the launch of a new gamification ... for a chance to win one of LabRoots most popular shirts. , Throughout each ...
Breaking Biology Technology:
Cached News: