HOME >> BIOLOGY >> NEWS
Antibody that neutralizes most HIV strains described by scientists at The Scripps Research Institute

A group of scientists from The Scripps Research Institute and several other institutions has solved the structure of a rare human antibody that broadly neutralizes human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS).

Neutralizing antibodies are soluble proteins that are secreted by adaptive immune cells into the bloodstream, following exposure to a virus. In the bloodstream, antibodies bind to viral particles in circulation, prevent them from infecting human cells, and lead to the viral particles' destructionthus neutralizing them.

Because neutralizing antibodies attack the virus before it enters cells, they can prevent HIV infection if they are present prior to exposure to the virus. An HIV vaccine would seek to elicit these neutralizing antibodies -- just as existing vaccines against diseases such as measles, polio, hepatitis B, and hepatitis A elicit neutralizing antibodies against those viruses.

However, this is easier said than done. The body makes many antibodies against HIV, but they are almost always unable to neutralize the virus. Nonetheless, the immune systems of some patients with HIV have beaten the odds and have produced effective neutralizing antibodies. The structure of one of these, called 4E10, is described in the latest issue of the journal Immunity.

"This antibody is very broadly active," says Scripps Research Professor Dennis Burton, Ph.D., who led the research with Scripps Research Professor Ian Wilson, D.Phil. "It neutralized nearly 100 different viral strains of HIV from all over the world. [During tests in the laboratory], every one of them was neutralized."

4E10 was isolated from an HIV-positive individual about a decade ago by Burton and Wilson's collaborator Hermann Katinger, a doctor at the Institute for Applied Microbiology of the University of Agriculture in Vienna, Austria, and one of the authors of the paper.

Significantly
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
22-Feb-2005


Page: 1 2

Related biology news :

1. Antibody-altering protein found in developing B cells
2. Antibody retards growth and induces death in liver cancer cells
3. Antibody linked to MS significantly higher in spinal fluid of blacks
4. Antibody-based therapies effective at controlling malaria
5. Antibody therapy prevents type 1 diabetes in mice
6. Antibody extends life of mice with breast cancer
7. Antibody to a naturally-occurring sugar chain in colon inhibits inflammatory bowel disease
8. Food preservative neutralizes anthrax spores
9. A treatment, not a cure: Calcium silicate neutralizes an acidic stream
10. Complexity constrains evolution of human brain genes
11. Newly identified strains of Chlamydia trachomatis could produce new diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
Breaking Biology News(10 mins):
(Date:8/17/2017)... ... August 17, 2017 , ... ... personalized medicine, today announced the launch of a new breast cancer monitoring study ... goal is to evaluate the potential for early detection of recurrent breast cancer ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... a different cell type. Many treatments for specific cancers, such as breast, prostate, ... targeted treatment is androgen deprivation therapy for advanced prostate cancer. , This ...
(Date:8/16/2017)... ... 2017 , ... We are proud to announce the successful ... Dilworth, MN site. The inspection took place Monday, July 31st through Friday, August ... a routine Bioresearch Monitoring Program (BIMO) with the USFDA wherein multiple Dermatology Vasoconstriction ...
(Date:8/15/2017)... 2017 After spending the past two years building a ... collection, GeneFo now offers this platform to healthcare stakeholders (hospitals, foundations, ... adherence, and data collection vis a vis their members, under their ... launch of this offer. ... ...
Breaking Biology Technology:
Cached News: