HOME >> BIOLOGY >> NEWS
Antidepressants stimulate new nerve cells in adult monkeys, may have implications for humans

WASHINGTON, DC May 4, 2007 In adult monkeys, an antidepressant treatment has induced new nerve cell growth in the hippocampus, a brain area responsible for learning and memory. A similar process may occur in humans, the research suggests, and may help explain the effectiveness of antidepressant treatments.

The results, the first from nonhuman primates, are similar to those previously seen in rodents. They suggest that creation of new nerve cells, a process known as neurogenesis, is an important part of antidepressant therapy. Researcher Tarique Perera, MD, at Columbia University, and colleagues observed changes in the number of brain cells in the dentate gyrus region of the hippocampus. The study is published in the May 2 issue of The Journal of Neuroscience.

The growth of new nerve cells in the hippocampus has been suggested as the way antidepressants work in rodents, says Eric Nestler, MD, PhD, of the University of Texas Southwestern Medical Center. "However, the clinical relevance of this action has remained controversial, in part, because of uncertainty as to whether similar neurogenesis occurs in humans," he says. "This finding further supports the potential clinical relevance of changes in neurogenesis seen in rodent models."

Perera and the team treated a group of monkeys with electroconvulsive shock (ECS), an animal version of the highly effective clinical antidepressant electroconvulsive therapy. They saw an increase in new nerve cells in the hippocampus. Over four weeks, a majority of these cells became mature neurons.

These brain changes were not a response to tissue damage, Perera says, because no evidence of increased cell death was found in the ECS treated animals. In fact, the researchers found that the ECS treatments increased production of a protein (BCL2) that protects neurons from damage.

"These findings support the hypothesis that induction of neurogenesis is a necessary component in
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
4-May-2007


Page: 1 2

Related biology news :

1. Cardiac patches stimulate regeneration, improve function after heart attack
2. Oxidative stress stimulates p38 MAPK-mediated tumor suppression
3. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
4. New vaccine stimulates colorectal cancer patients immune systems to fight cancerous cells
5. Harvard scientists identify compounds that stimulate stem cell growth in the brain
6. Sexual competition stimulates premature and repeated ejaculation in a mammal
7. Novel vaccine approach stimulates protective immunity against listeria
8. New study shows antibody-interleukin complexes stimulate immune responses
9. Carbon nanoparticles stimulate blood clotting, researchers report
10. New battery technology helps stimulate nerves
11. Component of plastic stimulates growth of certain prostate cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient ... that is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of ... 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting ...
(Date:7/1/2020)... ... 01, 2020 , ... Cure Glioblastoma, a registered 501(c)(3) nonprofit ... aggressive adult brain cancer—announced today the appointments of its first Senior Fellows: John ... the organization’s initiatives and overall vision. , "Senior Fellows are more than advisors; ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable ... testing operations in the fight against the COVID-19 pandemic in Zambia. , One ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Slone Partners , a ... the placement of Julianne Averill , CPA, as Chief Financial Officer at ... and implementing key business strategies to accelerate Alveo’s growth as the company advances ...
(Date:8/15/2020)... ... 13, 2020 , ... True Terpenes , the leading platform for terpene ... (SAB) to research the medical potential of terpenes and the potential entourage effect ... The board is focused on expanding the recently launched line of effects-based terpenes - ...
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society ... Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of ... a consortium of academic research centers in the United States and Europe with ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... International), a global leader in FDA compliance consulting has been named on its ... companies. The list represents a unique look at the most successful companies within ...
Breaking Biology Technology:
Cached News: