HOME >> BIOLOGY >> NEWS
Antioxidant overload may underlie a heritable human disease

Despite the popular notion that antioxidants, such as vitamins C and E, offer health-promoting benefits by protecting against damaging free radicals, a new study in the August 10 issue of the journal Cell reveals that, in fact, balance is the key. The researchers show in mice that an overload of natural antioxidants can actually lead the heart to failure.

There is plenty of evidence about the damaging effects of oxidative stress, but there is another side to the coin, said Ivor Benjamin of the University of Utah, Salt Lake City. There has been so much emphasis on free radicals to the exclusion of the potential consequences of reductants. Our study provides the first bona fide example of the role that reductive stress can play in disease.

Reductants, sometimes referred to as antioxidants, are elements or compounds that easily give up an electron to become oxidized, while oxidizing agents readily accept electrons. In the body, such oxidation-reduction (redox) reactions are integral to the release and storage of energy. Many cellular pathways are also sensitive to the prevailing redox condition.

Oxidative stress, which consumes reducing equivalents, has been often implicated in numerous cardiac and other diseases, Benjamin noted. However, the possibility remained that an inverse imbalance could provoke reductive stress, with the potential for similar deleterious effects. Indeed, reductive stress had been demonstrated in simpler organisms but not in mammals and/or disease states, he said.

In the current study, the researchers examined mice carrying a human mutation earlier linked to so-called protein aggregation skeletal myopathies and cardiomyopathies, in which weakening skeletal and heart muscle contain clumps of proteins. Although the genetic basis for the disease had been linked to mutations in one of two genes, the mechanism responsible remained mysterious.

The researchers now show that mice with one of the mutan
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
9-Aug-2007


Page: 1 2

Related biology news :

1. Antioxidant found in many foods and red wine is potent and selective killer of leukemia cells
2. Antioxidants decrease disease in a Drosophila model of Alzheimers disease
3. Antioxidants: New kid on the block for pain relief?
4. Antioxidant tempol prevents pre-eclampsia, decreases fetal mortality in mice
5. Antioxidant supplementation not associated with decreased risk of prostate cancer
6. Antioxidant-rich diets reduce brain damage from stroke in rats
7. Antioxidant blood levels key to MnSOD gene
8. Fat overload kills mammalian cells key culprit identified
9. Unexpected link between gene in liver and iron overload
10. Abnormal fat metabolism underlies heart problems in diabetic patients
11. Guardian of the genome protein found to underlie skin tanning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/25/2019)... ... September 25, 2019 , ... The esteemed dental implant specialists ... implants for a variety of procedures, including single tooth replacement, new “teeth-in-a-day” immediately ... Dental implants offer patients permanent tooth replacement solutions that look and function ...
(Date:9/24/2019)... ... 2019 , ... HT Medical today announced a ... with the expansion of its proprietary Ti3D® spinal interbody cages. Through this launch, ... cervical and lumbar instrumentation sets available for surgical use. , The additional Ti3D ...
(Date:9/17/2019)... SALT LAKE CITY (PRWEB) , ... September 17, ... ... Group SA, and a group of doctors, scientists and engineers from the Medical ... to present the results of their work to-date in creating a neuroprosthetic system ...
Breaking Biology News(10 mins):
(Date:10/8/2019)... ... 2019 , ... Erchonia Corporation, the global leader in the ... the U.S. Food and Drug Administration (FDA) has granted the company 510(k) market ... chronic neck and shoulder pain of musculoskeletal origin. , Erchonia continues to be ...
(Date:10/3/2019)... ... October 01, 2019 , ... Cheyenne is a beautiful and strong Quarter ... owns and operates Rebel’s Run , which offers riding lessons and trail riding ... trail riding guests. Mimi describes her as her “go to horse.” Thus, ...
(Date:10/3/2019)... ... October 02, 2019 , ... eKare’s inSight® digital 3D imaging and ... run by the East Midlands Academic Health Science Network (EMAHSN), the innovation arm of ... NHS by providing support to develop and deploy solutions to the most pressing challenges ...
(Date:9/30/2019)... , ... September 30, 2019 , ... ... science newsletter from Rigaku Corporation , is now available online on the ... X-ray based materials science, including X-ray diffraction, fluorescence and imaging, and presents articles, ...
Breaking Biology Technology:
Cached News: