HOME >> BIOLOGY >> NEWS
Antioxidant overload may underlie a heritable human disease

Despite the popular notion that antioxidants, such as vitamins C and E, offer health-promoting benefits by protecting against damaging free radicals, a new study in the August 10 issue of the journal Cell reveals that, in fact, balance is the key. The researchers show in mice that an overload of natural antioxidants can actually lead the heart to failure.

There is plenty of evidence about the damaging effects of oxidative stress, but there is another side to the coin, said Ivor Benjamin of the University of Utah, Salt Lake City. There has been so much emphasis on free radicals to the exclusion of the potential consequences of reductants. Our study provides the first bona fide example of the role that reductive stress can play in disease.

Reductants, sometimes referred to as antioxidants, are elements or compounds that easily give up an electron to become oxidized, while oxidizing agents readily accept electrons. In the body, such oxidation-reduction (redox) reactions are integral to the release and storage of energy. Many cellular pathways are also sensitive to the prevailing redox condition.

Oxidative stress, which consumes reducing equivalents, has been often implicated in numerous cardiac and other diseases, Benjamin noted. However, the possibility remained that an inverse imbalance could provoke reductive stress, with the potential for similar deleterious effects. Indeed, reductive stress had been demonstrated in simpler organisms but not in mammals and/or disease states, he said.

In the current study, the researchers examined mice carrying a human mutation earlier linked to so-called protein aggregation skeletal myopathies and cardiomyopathies, in which weakening skeletal and heart muscle contain clumps of proteins. Although the genetic basis for the disease had been linked to mutations in one of two genes, the mechanism responsible remained mysterious.

The researchers now show that mice with one of the mutan
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
9-Aug-2007


Page: 1 2

Related biology news :

1. Antioxidant found in many foods and red wine is potent and selective killer of leukemia cells
2. Antioxidants decrease disease in a Drosophila model of Alzheimers disease
3. Antioxidants: New kid on the block for pain relief?
4. Antioxidant tempol prevents pre-eclampsia, decreases fetal mortality in mice
5. Antioxidant supplementation not associated with decreased risk of prostate cancer
6. Antioxidant-rich diets reduce brain damage from stroke in rats
7. Antioxidant blood levels key to MnSOD gene
8. Fat overload kills mammalian cells key culprit identified
9. Unexpected link between gene in liver and iron overload
10. Abnormal fat metabolism underlies heart problems in diabetic patients
11. Guardian of the genome protein found to underlie skin tanning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... Lajollacooks4u is delighted to announce it ... which honors hospitality excellence, is given only to businesses that have achieved consistently outstanding ... consecutive years. , To qualify for the Certificate of Excellence –- an ...
(Date:6/1/2019)... ... May 31, 2019 , ... The University ... recently invested in BioFactura’s $6M Series B Financing Round. , “With the ... investors who bring significant financial and business resources to bear as we advance ...
(Date:5/31/2019)... ... May 30, 2019 , ... Researchers from Ambry ... documented significant differences in the prevalence of hereditary genetic mutations, also called germline ... White women. Results will be presented at the 2019 American Society of Clinical ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... California (PRWEB) , ... May ... ... of our patent applications from the USPTO providing proprietary interest to our ... METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including ...
(Date:5/22/2019)... ... 2019 , ... Artemis (formerly Agrilyst), the leading enterprise Cultivation Management ... co-led by Astanor Ventures and Talis Capital with participation from ... Fund . The company has raised $11.75m to date and will use the new ...
(Date:5/14/2019)... ... May 13, 2019 , ... ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is ... redesigned website aims to improve LDA’s ability to communicate directly with the marketplace; ...
(Date:5/4/2019)... Brazil (PRWEB) , ... May 03, 2019 , ... ... given by the President of the Dakila Pesquisas Association, the scientist and ufologist ... Councilmen 2019, in Brasília (DF). Urandir detailed the results of some research carried ...
Breaking Biology Technology:
Cached News: