HOME >> BIOLOGY >> NEWS
Antioxidant overload may underlie a heritable human disease

t genes, B-crystallin, specifically in the heart develop the same symptoms seen in human patients, including heart enlargement, progressive heart failure, and an early death. They further show that the animals hearts are under reductive stress.

The find initially took Benjamin by surprise, he said. They had conducted a test traditionally used to measure the level of oxidative stress in the animals, expecting they might see higher than normal levels. Instead, they found the mice had markedly reduced oxidative stress levels due to an abundance of a natural antioxidant known as glutathione.

The mutant mouse hearts exhibited a heightened stress response, including higher activity of heat shock proteins that have been documented in human heart failure, Benjamin explained. Such stress responses yield reactive oxygen species, triggering antioxidative pathways to kick in. In the diseased animals, however, that pathwayin which oxidized glutathione is recycled to its reduced, antioxidant formsoon got out of hand, producing excess levels of the reduced glutathione and a condition of reductive stress.

Moreover, they showed that the offspring of the heart-diseased animals and mice with lower levels of one of the antioxidant enzymes, glucose-6-phosphate dehydrogenase (G6PD), were relieved of their symptoms. That finding suggests that drugs or other treatments targeting the antioxidant pathway through G6PD might modify the phenotype and the natural history of this inherited disorder in humans, according to the researchers.

The results found in the heart suggest that reductive stress might underlie other diseases, as well. Our findings open up a whole new line of investigation in protein aggregation diseases, including neurodegenerative diseases such as Alzheimers and Huntingtons disease, Benjamin said.


'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
9-Aug-2007


Page: 1 2

Related biology news :

1. Antioxidant found in many foods and red wine is potent and selective killer of leukemia cells
2. Antioxidants decrease disease in a Drosophila model of Alzheimers disease
3. Antioxidants: New kid on the block for pain relief?
4. Antioxidant tempol prevents pre-eclampsia, decreases fetal mortality in mice
5. Antioxidant supplementation not associated with decreased risk of prostate cancer
6. Antioxidant-rich diets reduce brain damage from stroke in rats
7. Antioxidant blood levels key to MnSOD gene
8. Fat overload kills mammalian cells key culprit identified
9. Unexpected link between gene in liver and iron overload
10. Abnormal fat metabolism underlies heart problems in diabetic patients
11. Guardian of the genome protein found to underlie skin tanning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... SOUTHFIELD, Mich. (PRWEB) , ... August 11, 2020 ... ... Janssen R&D subsidiary based in Princeton, NJ, have entered into license agreements with ... discovery and development. Both Roche and J&J have annual Research and Development ...
(Date:8/7/2020)... SAN FRANCISCO (PRWEB) , ... August 06, 2020 ... ... the life sciences industry, is pleased to announce that Eric Chen and Jessica ... Vice President of Product Management & Strategy, respectively. , Eric Chen heads development ...
(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. (Nasdaq: ... advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene ... strategic partnership whereby Catalent will provide support for the development, manufacturing, and clinical ...
(Date:7/18/2020)... ... 16, 2020 , ... After research model surgery and catheter implantation, the long ... only the beginning of a successful study, while protecting and accessing the catheter or ... Head of Surgery from Envigo in a live webinar on ...
(Date:7/10/2020)... ... July 09, 2020 , ... PathSensors Inc., ... has expanded the company’s exclusive license to include clinical applications for CANARY™ ... market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ fast and highly ...
(Date:7/1/2020)... ... 29, 2020 , ... MedShift , a leading medical ... many obstacles created as a result of COVID-19. As a provider at the ... practices and medical manufacturers by expanding access to device offerings, technology services, and ...
Breaking Biology Technology:
Cached News: