HOME >> BIOLOGY >> NEWS
Atherosclerosis studied at the cellular level

A McMaster University study on atherosclerosis will be featured on the cover of the December issue of the high impact American Heart Association scientific journal, Arteriosclerosis, Thrombosis and Vascular Biology.

Richard Austin, PhD, and a team of researchers are studying the cellular and molecular mechanisms that accelerate the development and progression of atherosclerosis, the underlying cause of cardiovascular disease and stroke. These studies have provided important clues as to how changes in cell function contribute to this progressive and life threatening disease.

Dr. Austin, a professor in the department of Pathology and Molecular Medicine and a Career Investigator of the Heart and Stroke Foundation of Ontario, said the study found that nitric oxide, normally considered a "good player" in protection against atherosclerosis, could sometimes be converted into a toxic byproduct with a detrimental impact on cell viability and function.

"The results from our study show that under the right cellular conditions, such as the increased production of cellular oxidants, nitric oxide can be converted into a very "bad player", namely peroxynitrite," said Dr. Austin, a Staff Scientist who works at the Henderson Research Centre.

"Although previous reports have demonstrated that the generation of peroxynitrite in the vessel wall accelerates atherosclerosis, the cellular mechanism responsible for this effect was relatively unknown. Our study shows that the production of peroxynitrite causes cell dysfunction and death by activating or 'turning on' a cellular stress pathway, termed the ER stress response pathway.

Although activation of this pathway is considered to be protective, prolonged or severe ER stress induced by peroxynitrite can lead to devastating cytotoxic effects. In addition to these findings, we have reported previously that activation of this cellular stress pathway causes changes in lipid metabolism and inflamm
'"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
905-525-9140 x22169
McMaster University
1-Dec-2005


Page: 1 2

Related biology news :

1. Bacterial response to oxidation studied as toxin barometer
2. Ground spider diversity studied in research project
3. Fat stem cells being studied as option for breast reconstruction
4. Area creek studied for rangeland effects on water quality
5. Links between DNA damage and breast cancer studied
6. Inflammation and drugs to control this activity studied in a variety of tumors sites
7. Saharas edge studied from ground, air and space to improve water management
8. OT, VP studied as novel psychiatric drug sources; consider gender-specific drug models
9. Novel biotoxin being studied for use in opioid withdrawal
10. Insecticide resistance in mosquitoes being studied
11. MIT: Recycling of scrapped electronics studied

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... INDIANAPOLIS , Oct. 11, 2017  VMS BioMarketing, a ... of a nationwide oncology Clinical Nurse Educator (CNE) network, which ... growing need for communication among health care professionals to enhance ... physicians, nurses, office staff, and other health care professionals to ... for breast cancer. ...
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced the ... NIH to develop RealSeq®-SC (Single Cell), expected to be ... small RNAs (including microRNAs) from single cells using NGS ... the need to accelerate development of approaches to analyze ... "New techniques for measuring levels of mRNAs ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in ... professor in Harvard University’s Departments of Physics and Astronomy, has been selected for membership ... the winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery ...
Breaking Biology Technology:
Cached News: