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Attack is the best defence against urinary tract infection

few minutes after a bacterial attack," says Professor Brauner.

Experiments on mice showed that animals lacking the gene for an antimicrobial peptide almost identical to the human peptide LL-37 are more vulnerable to urinary tract infection. In such animals, the infection was often more serious and the kidneys more swollen and full of bacteria.

"Urinary tract infection is not only painful for the patient, but also an economical burden to the individual and society," says Professor Brauner. "Our findings point to a new way to prevent the development of urinary tract infection by boosting the antibacterial peptide LL-37. For patients suffering from recurrent urinary tract infection, attack would quite simply be the best form of defence."


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Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-70-224-3895
Karolinska Institutet
4-Jun-2006


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