HOME >> BIOLOGY >> NEWS
BEMA Fentanyl demonstrates substantial transmucosal delivery

Morrisville, North Carolina, May 7, 2007 -- BioDelivery Sciences International, Inc. (Nasdaq:BDSI) announced the results of a 12 subject, crossover study comparing the absorption of fentanyl from both single and multiple BEMA Fentanyl discs, as well as oral and intravenous doses of fentanyl. The data demonstrates that the absolute bioavailability (i.e. the total amount absorbed from the delivery system) of fentanyl through the BEMA disc was more than 70%, with 50% absorbed through the buccal mucosa (the inner lining of the cheek). The study further demonstrates that equal doses administered as either a single disc or multiple discs produced nearly identical plasma concentrations (i.e. two 200 mcg discs provided nearly equivalent plasma concentrations as one 400 mcg disc, etc.)

These findings follow the Companys April 25, 2007 announcement of statistically significant results with BEMA Fentanyl in treating cancer patients with breakthrough pain in the companys Phase III efficacy clinical trial. BDSI plans to include todays study results, the efficacy trial results and other materials in its planned submission of a New Drug Application (NDA) to the FDA for BEMA Fentanyl. The NDA submission is expected during third quarter of 2007.

BEMA Fentanyl consists of a small, dissolvable polymer disc, formulated with the opioid narcotic fentanyl, for application to the buccal membranes. Upon administration, BEMA Fentanyl is designed to deliver a rapid, reliable dose of drug across mucous membranes. BEMA Fentanyl is being developed for the treatment of "breakthrough" cancer pain (i.e. episodes of severe pain which "break through" the medication already in use to control the persistent pain).

Dr. Andrew Finn, Executive Vice President of Product Development for BDSI, stated "The results of this study confirm, and are an expansion of, the information obtained in our 2006 pharmacokinetic study which demonstrated that fentanyl absorption from th
'"/>

Contact: Bill Douglass
bill@investorrelationsgroup.com
BioDelivery Sciences
7-May-2007


Page: 1 2 3

Related biology news :

1. New study demonstrates important role of glia in circadian timing
2. Stowers Institutes Workman Lab demonstrates mechanism for decoding histone modification marks
3. Xie Lab demonstrates the role of microRNA pathway
4. Rong Li Lab demonstrates the process of mammalian egg maturation
5. Compelling evidence demonstrates that Hobbit fossil does not represent a new species of hominid
6. OHSU research demonstrates possible health risks for children born to overeating mothers
7. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
8. NYUS Childress demonstrates tool for studying hovering flight at international science meeting
9. Study demonstrates rapid diagnosis of urinary tract infections with biosensor technology
10. Report demonstrates safety of nuclear medicine procedures
11. New study shows Emezine demonstrates more efficient absorption

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... 2019 , ... An upcoming episode of Advancements with Ted ... helping to promote normal immune function in order to prevent and fight cancer. ... DECODE.DESIGN.CURE™ technology platform, which rapidly develops microbiome therapeutics in order to enable a ...
(Date:8/14/2019)... ... August 13, 2019 , ... Join Anguraj Sadanandam, PhD, Team ... Cancer Research (ICR) in a live webinar on Wednesday, September 4, ... and companion diagnostic development including machine learning approaches in different gastrointestinal cancers and ...
(Date:8/6/2019)... , ... August 05, 2019 , ... Keck Graduate Institute ... School of Pharmacy and Health Sciences (SPHS). , “Dean Zdanowicz is highly regarded as ... Trustees Chairman Jim Widergren. “He is a great choice to build on the success ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... 22, 2019 , ... An upcoming episode of Advancements with ... 4Q/2019. Check your local listings for more information. , This segment will educate ... on therapeutics for children and the elderly, viewers will learn about Avro’s core ...
(Date:8/7/2019)... ... 07, 2019 , ... Locus Agricultural Solutions (Locus AG) reports record levels of ... including Rhizolizer ® , which is pulling up to 121% more carbon into ... to date. Results from the treatment of almonds, cherries, turf/sod, grapes and citrus across ...
(Date:8/4/2019)... ... 02, 2019 , ... Cirtec Medical Corporation, a strategic outsourcing partner for complex ... begun construction on a 30,000 sq. ft. manufacturing facility in the Coyol free ... The facility, which is expected to be fully operational by the end of the ...
(Date:7/19/2019)... ... July 18, 2019 , ... World renowned ... be joining forces with California-based charity Coalition Duchenne for its 9th Annual Expedition ... raises awareness and funding for Duchenne muscular dystrophy and was founded by Sabahan ...
Breaking Biology Technology:
Cached News: