HOME >> BIOLOGY >> NEWS
BRCA2 carriers at increased risk for deadly form of prostate cancer

Carriers of a BRCA2 variation specific to Iceland are more likely to develop aggressive and lethal prostate cancer than noncarriers, according to a study published online June 12 in the Journal of the National Cancer Institute.

Mutations in the BRCA2 gene are associated with increased prostate cancer risk, but it has been unclear whether they are related to progression of the disease.

Laufey Tryggvadttir of the Icelandic Cancer Registry and colleagues compared survival and disease progression in prostate cancer patients with the Icelandic BRCA2 999del5 founder mutation and those without the mutation. Using a pool of male relatives of women with breast cancer, researchers identified prostate cancer patients diagnosed in Iceland between 1955 and 2004. The mutation was present in 30 patients (5.7%).

The mutations carriers were younger at the time of diagnosis and had more advanced staged cancer, higher-grade tumors, and shorter median survival time (2.1 years vs. 12.4 years) compared with noncarriers.

The authors conclude that it is of great importance to study whether these results can be confirmed for carriers of mutations at other locations within the BRCA2 gene. Finally, the results indicate that in the search for new methods to predict prostate cancer progression, it may be fruitful to look for gene or protein expression patterns in prostate cancers resembling the patterns seen in BRCA2 mutation carriers.

In an accompanying editorial, Sholom Wacholder, Ph.D., of the National Cancer Institute in Bethesda, Md., and colleagues discuss the limitations of this study and other similar studiesthe small number of mutation carriers, changes in screening practices, and the assumption that the date of diagnosis corresponds with the time of disease onset.

This work may clarify when and how BRCA2 mutations alter carcinogenesis. More generally, it offers an avenue for improving the accuracy of information
'"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
12-Jun-2007


Page: 1 2

Related biology news :

1. More common associations found between BRCA1 and BRCA2 mutations and cancer
2. EPO upholds limited patent on BRCA2 gene
3. Cambridge led team discovers gene mutation which prevents carriers from feeling pain
4. Wild gorillas carriers of a SIV virus close to the AIDS virus
5. Scientists develop a new diagnostic approach for carriers of recessive genetic disorders
6. Study estimates melanoma risk in gene mutation carriers
7. Gene variations directly link inflammation to an increased risk for lung cancer
8. Salvage logging, replanting increased biscuit fire severity
9. Gene mutation linked to increased athletic performance in whippets
10. Scientist advocates increased fisheries data gathering
11. A unique twin study on the increased cardiometabolic risk in obesity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/7/2019)... ... January 07, 2019 , ... Franz Inc. , an ... for Knowledge Graphs solutions, announced that it was recognized by Database Trends ... data and information management recognition list includes newer approaches leveraging artificial intelligence, machine ...
(Date:1/4/2019)... ... January 02, 2019 , ... ... particularly noteworthy, as the life science tools and service supplier turned 40 in ... a catalog. The catalog features not just part numbers like most catalogs, but ...
(Date:1/4/2019)... ... 03, 2019 , ... Stay on top of current hot topics through free ... to all webinars is free, so be sure to register today to save your ... to check out our upcoming webinars, or click below to learn more about ...
Breaking Biology News(10 mins):
(Date:2/2/2019)... , ... January 31, 2019 , ... Dust off your ... as it hosts the Nuriv 2019 Expo West Music and Tech Festival at the ... to foster innovation in the natural foods, beverages, and dietary supplement industries, the Nuriv ...
(Date:1/30/2019)... ... January 29, 2019 , ... Mr. Schieving has ... his position as Director of Sales and Marketing, Mr. Schieving was instrumental in ... industries the company supports. During this time, Mr. Schieving was responsible for establishing ...
(Date:1/30/2019)... FRANCISCO (PRWEB) , ... January 30, 2019 , ... ... leader in microbial genomics, has awarded microbiome research support in study design, planning, ... State University led by Dr. Marc D. Cook, PhD, to study the interactions ...
(Date:1/24/2019)... ... , ... Outsourcing trials to contract research organizations (CRO) can ... creation and management generally requires manual effort. Additionally, each vendor organizes tasks and ... can ultimately lead to study start delays and change orders because tasks were ...
Breaking Biology Technology:
Cached News: