HOME >> BIOLOGY >> NEWS
BRCA2 carriers at increased risk for deadly form of prostate cancer

Carriers of a BRCA2 variation specific to Iceland are more likely to develop aggressive and lethal prostate cancer than noncarriers, according to a study published online June 12 in the Journal of the National Cancer Institute.

Mutations in the BRCA2 gene are associated with increased prostate cancer risk, but it has been unclear whether they are related to progression of the disease.

Laufey Tryggvadttir of the Icelandic Cancer Registry and colleagues compared survival and disease progression in prostate cancer patients with the Icelandic BRCA2 999del5 founder mutation and those without the mutation. Using a pool of male relatives of women with breast cancer, researchers identified prostate cancer patients diagnosed in Iceland between 1955 and 2004. The mutation was present in 30 patients (5.7%).

The mutations carriers were younger at the time of diagnosis and had more advanced staged cancer, higher-grade tumors, and shorter median survival time (2.1 years vs. 12.4 years) compared with noncarriers.

The authors conclude that it is of great importance to study whether these results can be confirmed for carriers of mutations at other locations within the BRCA2 gene. Finally, the results indicate that in the search for new methods to predict prostate cancer progression, it may be fruitful to look for gene or protein expression patterns in prostate cancers resembling the patterns seen in BRCA2 mutation carriers.

In an accompanying editorial, Sholom Wacholder, Ph.D., of the National Cancer Institute in Bethesda, Md., and colleagues discuss the limitations of this study and other similar studiesthe small number of mutation carriers, changes in screening practices, and the assumption that the date of diagnosis corresponds with the time of disease onset.

This work may clarify when and how BRCA2 mutations alter carcinogenesis. More generally, it offers an avenue for improving the accuracy of information
'"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
12-Jun-2007


Page: 1 2

Related biology news :

1. More common associations found between BRCA1 and BRCA2 mutations and cancer
2. EPO upholds limited patent on BRCA2 gene
3. Cambridge led team discovers gene mutation which prevents carriers from feeling pain
4. Wild gorillas carriers of a SIV virus close to the AIDS virus
5. Scientists develop a new diagnostic approach for carriers of recessive genetic disorders
6. Study estimates melanoma risk in gene mutation carriers
7. Gene variations directly link inflammation to an increased risk for lung cancer
8. Salvage logging, replanting increased biscuit fire severity
9. Gene mutation linked to increased athletic performance in whippets
10. Scientist advocates increased fisheries data gathering
11. A unique twin study on the increased cardiometabolic risk in obesity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to ... a near term focus on Type 2 diabetes and associated comorbidities. , Justin ... therapeutic areas and classes. As Chief Commercial Officer, Justin will lead Better ...
(Date:7/18/2020)... ... ... Commercial launch readiness is a critical stage in a product life cycle. ... the global economic downturn will only increase price pressures overall for the industry. The ... value from every product launch is critical. However, history shows that only a third ...
(Date:7/4/2020)... PHOENIX (PRWEB) , ... July 03, 2020 , ... ... is proud to earn outstanding recognition and multiple awards for not only the ... the ABM portfolio, SoME® Skincare and Vivace® Microneedle RF. All the brands built ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... ... biotechnology, and diagnostics companies, has announced the placement of Julianne Averill , ... responsible for leading all financial operations and implementing key business strategies to accelerate ...
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society ... Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of ... a consortium of academic research centers in the United States and Europe with ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... Mass. (PRWEB) , ... July 29, 2020 , ... ... highly reliable, solid-state radar transmitter systems that can be configured to drive Klystrons, ... single controller that can drive one or two switches in a push-pull configuration; ...
Breaking Biology Technology:
Cached News: