Tullius's research will give scientists a finely detailed picture of how the most fundamental aspects of naked DNA -- DNA without proteins bound to its surface -- influence its function.
Tullius is one of six principal investigators to receive technology development grants from NHGRI, a part of the National Institutes of Health. The new grants, which total $5.5 million, represent the latest infusion of support to researchers selected for ENCODE projects. ENCODE, or encyclopedia of DNA elements, picks up the search for understanding the human genome where the Human Genome Project left off. Composed of scientists from government, industry, and academia from throughout the world, ENCODE is dedicated to producing a comprehensive catalog of elements crucial to biological function in the roughly 98 percent of the human genome that does not code for proteins.
ENCODE researchers are bringing their individual investigations to bear on a particular 1 percent of the genome selected by ENCODE coordinators at NHGRI. Tullius's research on this designated genomic neighborhood aims to decipher the patterns of its landscape and, in the process, build tools that researchers can use to map protein-binding sites.
His research has three goals: to build a database of patterns of DNA's sequence and structure found using a special probe, to develop computational methods that can predict these patterns in any sequence of DNA, and to use these experimental an
Contact: Ann Marie Menting