The researchers, led by Olivier S. Descamps of the Centre de Recherche Mdicale de Jolimont in Haine Saint-Paul and of the Universit Catholique de Louvain in Brussels, studied genes and proteins involved in fat metabolism from the blood and placenta of 525 pregnant women. Because all cells from the placenta originate from the fetus, they are a good indication of the genes and proteins produced by the baby.
Descamps and his co-workers discovered that the baby's genes had almost as much influence as the mother's genes on her lipoprotein levels. Because increased levels of lipoproteins can lead to pre-eclampsia and pancreatitis in pregnant women and also increase their future risk of cardiovascular disease, these findings are of particular interest to the medical community.
"The lipoprotein particle is composed of proteins called apolipoproteins and lipids such as cholesterol and triglycerides." explains Descamps. "Lipoproteins represent the only way for lipids, which are insoluble in water, to be transported through the blood circulation, composed exclusively of water."
The study focused on two specific proteins involved in lipid metabolism, lipoprotein lipase and apolipoprotein E. "Apolipoprotein E and lipoprotein lipase play important roles in the degradation of triglyceride-rich lipoproteins," notes Descamps. "In pregnant women, the concentrations of these lipoproteins are particularly very high and it is thought that these lipoproteins are the forms that carry the lipids to the placenta.
The researchers looked at several genetic variations (also known as polymorphisms) of lipoprotein li
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Contact: Nicole Kresge
nkresge@asbmb.org
301-634-7415
American Society for Biochemistry and Molecular Biology
27-Oct-2005