HOME >> BIOLOGY >> NEWS
Bacteria control how infectious they become, study finds

COLUMBUS, Ohio The results of a new study suggest that bacteria that cause diseases like bubonic plague and serious gastric illness can turn the genes that make them infectious on or off.

Knowing how disease-causing bacteria, like Yersinia pestis and E. coli, do this may one day help scientists create drugs that control the expression of these genes, thereby making the bacteria harmless, said Vladimir Svetlov, a study co-author and a research associate in microbiology at Ohio State University. The findings appear in the April 13 issue of the journal Molecular Cell.

Gene expression the process of turning on, or activating, genes is controlled by proteins called transcription factors. Every type of bacteria known to humankind contains the transcription factor NusG, which controls nearly all of a bacterium's gene expression. Without it, a microorganism will die.

We think that NusG regulates nearly every gene in every form of bacteria, said Irina Artsimovitch, the study's lead author and an associate professor of microbiology at Ohio State . Say a bacterium has 3,000 genes NusG would regulate 2,900 of them.

But somewhere along the evolutionary path, NusG was copied and physically changed. The result was a specialized transcription factor called RfaH. Unlike NusG, RfaH controls only a small portion of gene expression. But it happens to turn on those genes that give bacteria like E. coli and Y. pestis their ability to infect.

The researchers say that this study likely marks the first successful attempt by a laboratory to determine the structure of RfaH.

They used special X-ray techniques to study and describe RfaH proteins that they had extracted from E. coli. They found that while about two-thirds of RfaH's structure closely resembles the structure of NusG, the remaining one-third looked dramatically different. It's this latter third that appears to be the portion of the protein responsible for controllin
'"/>

Contact: Vladimir Svetlov
Svetlov.1@osu.edu
614-688-3561
Ohio State University
12-Apr-2007


Page: 1 2 3

Related biology news :

1. Bacteria may not hasten death
2. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
3. Bacteria ferry nanoparticles into cells for early diagnosis, treatment
4. Bacteria show promise in fending off global amphibian killer
5. Better together: Bacterial endosymbionts are essential for the reproduction of a fungus
6. Bacterial response to oxidation studied as toxin barometer
7. Bacteria from patients dental plaque causes ventilator-associated pneumonia
8. Bacterial walls come tumbling down
9. Bacteria could steady buildings against earthquakes
10. Bacteria research offers hope for new vaccine against meningococci
11. Bacteria in small sea life yield new way to make potential cancer drugs

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bacteria control how infectious they become study finds

(Date:7/20/2015)... -- Acuity Market Intelligence,s latest research "The Global Biometrics ... Privacy" forecasts that between 2014 and 2020 nearly ... to smart mobile devices by 2.2 billion mobile ... to generate more than $67.9 billion in total ...    "Biometrics is at the center ...
(Date:7/9/2015)... , July 07, 2015 ... announced the addition of the "Biometrics for ... Forecasts 2015-2020" report to their offering. ... major contributor to this growth and the forecast ... billion in revenue for companies involved in delivering ...
(Date:7/8/2015)... NEW YORK , July 8, 2015  BD ... announced BD & Guidepoint Mentor, a new ... to Guidepoint,s expert network services. BD ... technologies to improve healthcare delivery and outcomes and, with ... start-up entrepreneur will be able to directly engage with ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
(Date:7/29/2015)... ... 29, 2015 , ... Available in select spas and ... nighttime-specific product that targets fat cells for extreme contouring action. During sleep key ... cells, inhibiting the formation of new fat. Upon waking CHRONODIET breaks down fat ...
(Date:7/29/2015)... ... July 29, 2015 , ... Nearly everyone has heard of the potential ... realize that a rich source of these cells is teeth—baby teeth that come loose ... to be pulled to make room for braces. These potent stem cells exist ...
(Date:7/28/2015)... Nev. , July 28, 2015  PDL BioPharma, ... today announced that the Company will release its second ... 30, 2015, on Wednesday, August 5, 2015, after market ... webcast that day at 4:30 p.m. Eastern Time to ... the call will be available via the webcast link ...
(Date:7/28/2015)... July 21, 2015 ... the addition of the "Analysis of the ... their offering. Globally, flow cytometry remains ... cell proliferation, cancer, and stem cells. But the ... primarily because of demand from underdeveloped nations to ...
Breaking Biology Technology:Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3Advanced Oral and Maxillofacial Surgery (AOMS) in Elmhurst, IL Partners with Provia Labs to make Store-A-Tooth™ Dental Stem Cell Banking Available to their Patients 2PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2Analysis of the Global Flow Cytometry Market 2012-2018 with a 2014 Base Year and a 2015-2018 Forecast Period 2
Cached News: