HOME >> BIOLOGY >> NEWS
Bacteria control how infectious they become, study finds

COLUMBUS, Ohio The results of a new study suggest that bacteria that cause diseases like bubonic plague and serious gastric illness can turn the genes that make them infectious on or off.

Knowing how disease-causing bacteria, like Yersinia pestis and E. coli, do this may one day help scientists create drugs that control the expression of these genes, thereby making the bacteria harmless, said Vladimir Svetlov, a study co-author and a research associate in microbiology at Ohio State University. The findings appear in the April 13 issue of the journal Molecular Cell.

Gene expression the process of turning on, or activating, genes is controlled by proteins called transcription factors. Every type of bacteria known to humankind contains the transcription factor NusG, which controls nearly all of a bacterium's gene expression. Without it, a microorganism will die.

We think that NusG regulates nearly every gene in every form of bacteria, said Irina Artsimovitch, the study's lead author and an associate professor of microbiology at Ohio State . Say a bacterium has 3,000 genes NusG would regulate 2,900 of them.

But somewhere along the evolutionary path, NusG was copied and physically changed. The result was a specialized transcription factor called RfaH. Unlike NusG, RfaH controls only a small portion of gene expression. But it happens to turn on those genes that give bacteria like E. coli and Y. pestis their ability to infect.

The researchers say that this study likely marks the first successful attempt by a laboratory to determine the structure of RfaH.

They used special X-ray techniques to study and describe RfaH proteins that they had extracted from E. coli. They found that while about two-thirds of RfaH's structure closely resembles the structure of NusG, the remaining one-third looked dramatically different. It's this latter third that appears to be the portion of the protein responsible for controllin
'"/>

Contact: Vladimir Svetlov
Svetlov.1@osu.edu
614-688-3561
Ohio State University
12-Apr-2007


Page: 1 2 3

Related biology news :

1. Bacteria may not hasten death
2. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
3. Bacteria ferry nanoparticles into cells for early diagnosis, treatment
4. Bacteria show promise in fending off global amphibian killer
5. Better together: Bacterial endosymbionts are essential for the reproduction of a fungus
6. Bacterial response to oxidation studied as toxin barometer
7. Bacteria from patients dental plaque causes ventilator-associated pneumonia
8. Bacterial walls come tumbling down
9. Bacteria could steady buildings against earthquakes
10. Bacteria research offers hope for new vaccine against meningococci
11. Bacteria in small sea life yield new way to make potential cancer drugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics ... recognition and multiple awards for not only the products and treatments developed, but ... and Vivace® Microneedle RF. All the brands built by ABM have received several ...
(Date:6/28/2020)... ... June 25, 2020 , ... Genedata, ... that it has entered into a multi-year contract with Merus N.V., a ... translational and clinical research strategy to discover and develop ground-breaking drugs. The ...
(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around for a ... of mass spectrometry in this field has gained a lot of momentum in the ... approach to use (LBA or MS)?” In many cases, either technology can answer ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... Modality ... for free its new white paper – Simulated Transport Methodologies. Regulatory expectations ... biologics licensing application (BLA). In response, Modality Solutions shares an explanation of ...
(Date:8/3/2020)... ... August 03, 2020 , ... ERT, ... President and CEO has been named one of the 100 most inspiring individuals ... PharmaVoice 100 honorees are selected based on how they have inspired their colleagues ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON ... of its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes ... globe, requiring fast track capacity to provide patients with urgently needed vaccines and ...
(Date:7/31/2020)... and SOMERSET, N.J (PRWEB) , ... July 29, ... ... genome editing company, and Catalent, the leading global provider of advanced delivery technologies, ... health products, today announced that they have entered into a strategic partnership whereby ...
Breaking Biology Technology:
Cached News: