HOME >> BIOLOGY >> NEWS
Bacteria have their own immune system protecting against outside DNA

Bacteria like Salmonella have a complicated immune system that helps them recognize and isolate foreign DNA trying to invade their cell membrane, according to a University of Washington-led study in the June 8 issue of Science Express. The research, which also included scientists at the Sidney Kimmel Cancer Center in San Diego, could have major implications for understanding the evolution of disease-causing bacteria. The findings may also impact the biotech industry, where bacteria are used to produce recombinant human proteins for medical treatments and research.

A group of researchers led by Dr. Ferric Fang, professor of laboratory medicine and microbiology at the UW School of Medicine, were interested in learning how bacteria respond to genetic information coming from outside sources. Just as immune cells recognize and attack foreign invaders in the human body to protect against harmful infections, single-cell organisms have a protein called H-NS that recognizes foreign DNA and prevents it from becoming active, the researchers discovered.

But bacteria can also benefit from foreign DNA. When Salmonella is infecting an animal or person, for instance, many proteins the bacteria need to cause disease are encoded by DNA acquired from other bacteria. The researchers found that when the bacteria is infecting a host, other molecules can compete with the H-NS protein, allowing the disease-causing genes to be expressed. When the bacteria are in the environment, H-NS turns these genes off to avoid detrimental consequences if all the disease-causing genes were to be expressed at once.

These findings give scientists new insight into how bacteria can protect themselves from an invasion by foreign DNA, yet still take in genetic information from diverse sources that makes them more virulent.

"By harnessing foreign DNA, bacteria that cause typhoid, dysentery, cholera and plague have evolved from harmless organisms into feared pathogens," explained Dr. Willia
'"/>

Contact: Justin Reedy
jreedy@u.washington.edu
206-685-0382
University of Washington
8-Jun-2006


Page: 1 2

Related biology news :

1. Bacteria may not hasten death
2. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
3. Bacteria ferry nanoparticles into cells for early diagnosis, treatment
4. Bacteria show promise in fending off global amphibian killer
5. Bacteria control how infectious they become, study finds
6. Better together: Bacterial endosymbionts are essential for the reproduction of a fungus
7. Bacterial response to oxidation studied as toxin barometer
8. Bacteria from patients dental plaque causes ventilator-associated pneumonia
9. Bacterial walls come tumbling down
10. Bacteria could steady buildings against earthquakes
11. Bacteria research offers hope for new vaccine against meningococci

Post Your Comments:
(Date:8/22/2014)... CAEveryone,s heard of the birds and the bees. ... that are being fertilized. The fertilization process for ... communication between the male and female reproductive cells. ... Regensburg, Heidelberg, and Munich, and including Carnegie,s Wolf ... in the chemical signaling process that guides flowering ...
(Date:8/21/2014)... SHELTON, Conn. , Aug. 21, 2014 ... on the growing mobile commerce market, announced today that ... purchase common stock to be issued in its proposed ... been approved for listing on The Nasdaq Capital Market, ... of the common stock and warrants, and will trade ...
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- LiveScan ... has agreed to a partnership with Gabriel Health ... fastest growing Certified Nursing Assistant preparatory ... Institute  an exclusive member of Binary,s LiveScan service ... Biometrics will improve its service capabilities by ...
Breaking Biology News(10 mins):Calcium and reproduction go together 2Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3
(Date:8/22/2014)... DUBLIN , Aug. 22, 2014 ... the "Global Molecular Biology Enzymes, Kits, & Reagents ... to 2018" report to their offering. ... at $2,847.63 million in 2013, and is expected to ... million in 2018. Molecular biology enzymes, kits, & reagents ...
(Date:8/22/2014)... Greenville, SC (PRWEB) August 22, 2014 ... that indisputable acknowledgement is a national disgrace. Furthermore, ... part in establishing the current, deplorable state of ... outlined "5 great mistakes," to merely serve as ... convey the extent of colossal failure(s) that have ...
(Date:8/21/2014)... research team including DESY scientists has observed tiny quantum ... reports in the journal Science that the ... the nanodroplets. It is the first time that the ... samples of what is known as superfluid helium, have ... best expectations," says Andrey Vilesov of the University of ...
(Date:8/21/2014)... 21, 2014 Telomere Biosciences, LLC (Telomere ... "TELO-20 for Dogs" with Telomerase Activation Complex ... the world for dogs. Telomeres are the protective ... the body. A wealth of ground-breaking research by ... Science and Aging, including Nobel laureates, has demonstrated ...
Breaking Biology Technology:Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 35 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Scientists observe quantum vortices in cold helium droplets 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3
Cached News: