HOME >> BIOLOGY >> NEWS
Bacteria have their own immune system protecting against outside DNA

m Navarre, a senior fellow at the UW and primary author of the study. "This research gives us an explanation of how pathogenic bacteria have evolved over millions of years."

The researchers also learned that the H-NS protein is able to recognize foreign DNA on the basis of its increased content of adenine and thymine, the building blocks of DNA.

"It has been a great mystery why disease-causing genes of bacteria usually contain more adenine and thymine," said Michael McClelland, professor and director of the Molecular Biology Program at the Kimmel Cancer Center. "Now we know this is because such sequences are easier to recruit and regulate than other DNA."

This research could also have major implications for the biotech industry, which uses bacteria for the production of recombinant proteins for medicine and research. These proteins, such as insulin or human growth hormone, are created when a piece of human DNA corresponding to that protein is introduced into bacteria. The bacteria then reproduce many times over, creating more of the protein each time they reproduce. The proteins are purified out from the bacteria, leaving behind only the useful protein. However, in that process, the yield of some human proteins produced in bacteria can be low. The new research indicates that the H-NS "immune system" may be responsible for interfering with the expression of human genes in bacteria.

"Having a better understanding of this system could help the biotech industry make recombinant proteins more efficiently," said Fang. "More foreign protein can be produced in bacteria that don't have the H-NS molecule."


'"/>

Contact: Justin Reedy
jreedy@u.washington.edu
206-685-0382
University of Washington
8-Jun-2006


Page: 1 2

Related biology news :

1. Bacteria may not hasten death
2. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
3. Bacteria ferry nanoparticles into cells for early diagnosis, treatment
4. Bacteria show promise in fending off global amphibian killer
5. Bacteria control how infectious they become, study finds
6. Better together: Bacterial endosymbionts are essential for the reproduction of a fungus
7. Bacterial response to oxidation studied as toxin barometer
8. Bacteria from patients dental plaque causes ventilator-associated pneumonia
9. Bacterial walls come tumbling down
10. Bacteria could steady buildings against earthquakes
11. Bacteria research offers hope for new vaccine against meningococci

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: