HOME >> BIOLOGY >> NEWS
Bacteria in small sea life yield new way to make potential cancer drugs

SALT LAKE CITY -- Researchers led by a University of Utah medicinal chemist have developed a novel method to make drugs for cancer and other diseases from bacteria found in sponges and other small ocean creatures.

In a study published Sunday, Nov. 5, in Nature Chemical Biology online, researchers examined symbiotic bacteria that live only in sea squirts and other marine life. These bacteria are responsible for making a wealth of chemicals, which accumulate in the tissues of sea squirts and may help to defend them against predators. Many of these chemicals have anticancer properties, but harvesting them in quantities for large-scale testing and production has been impractical.

The new method uses genetic pathways in the bacteria to produce the small chemicals and to manipulate them to invent new potential drugs. The ability to make these chemicals in the laboratory opens myriad possibilities for developing drugs to fight cancer, HIV, and other diseases, according to Eric W. Schmidt, Ph.D., assistant professor of medicinal chemistry at the University of Utah College of Pharmacy and senior author on the study.

"This represents a new way of attacking the problem," Schmidt said. "We're hoping we can use this to find a way to make natural molecules of compounds through single mutations in DNA."

To synthesize natural compounds, researchers have traditionally made them in the lab using labor-intensive routes. More recently, researchers have begun to use genes to make small molecules within laboratory strains of bacteria. This genetic synthesis method is complicated because it's still difficult to understand how changing genes can lead to changes in small drug molecules.

"The promise of genes is that you can access the tremendous natural diversity of the world's organisms to find new natural compounds for human health," Schmidt said. "You can also use genetic engineering to modify these compounds and invent new drugs to
'"/>

Contact: Phil Sahm
Phil.Sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences Center
5-Nov-2006


Page: 1 2

Related biology news :

1. Bacteria may not hasten death
2. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
3. Bacteria ferry nanoparticles into cells for early diagnosis, treatment
4. Bacteria show promise in fending off global amphibian killer
5. Bacteria control how infectious they become, study finds
6. Better together: Bacterial endosymbionts are essential for the reproduction of a fungus
7. Bacterial response to oxidation studied as toxin barometer
8. Bacteria from patients dental plaque causes ventilator-associated pneumonia
9. Bacterial walls come tumbling down
10. Bacteria could steady buildings against earthquakes
11. Bacteria research offers hope for new vaccine against meningococci

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2019)... ... August 22, 2019 , ... ... following their acquisition in June of 2018. Along with the name change, this ... , “Our goal was to create a cohesive brand that blended our core ...
(Date:8/19/2019)... ... August 19, 2019 , ... Since the microscope was first ... dimensional slices which are placed on microscope slides, stained and visualized by a ... features such as vasculature and thus researchers in the last few years have ...
(Date:8/14/2019)... , ... August 14, 2019 , ... ... 4Q/2019, will explore how developments in microbiome therapeutics are helping to promote normal ... for more information. , Advancements will educate about the DECODE.DESIGN.CURE™ technology platform, which ...
Breaking Biology News(10 mins):
(Date:8/15/2019)... ... August 15, 2019 , ... PathSensors announced today that ... member of the Institute of Food Technologists (IFT) Board of Directors, Illinois Institute ... Institute for Food Safety and Applied Nutrition (JIFSAN) Advisory Council and the University ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... on prepackaged mobile phases for QC laboratories. After gaining a few significant clients, ... sciences approach into a valued supplier of manufacturing processing solutions, including reagents for ...
(Date:8/7/2019)... ... August 07, 2019 , ... Locus Agricultural Solutions (Locus AG) reports record levels ... “probiotics”), including Rhizolizer ® , which is pulling up to 121% more carbon ... offered to date. Results from the treatment of almonds, cherries, turf/sod, grapes and citrus ...
(Date:8/6/2019)... ... August 06, 2019 , ... ... characterizing microbiome populations down to the strain level, has announced partnerships with six ... other products to companies and research organizations in Australia, Benelux, Indonesia, Korea, Malaysia, ...
Breaking Biology Technology:
Cached News: